Anne M. Larson
Clinical Professor
Medicine
Division of Gastroenterology
Clinic Chief, UW Medicine/Northwest Hospital Liver Clinic

Faculty Information

Biography

Anne Larson, M.D., F.A.A.S.L.D., A.G.A.F., F.A.C.P., is chief of UW Medicine’s Northwest Hepatology Clinic and a UW professor of Medicine. 

Dr. Larsen is a nationally recognized clinician, researcher and lecturer, the author of numerous peer-reviewed publications, and is recognized as a leader in the field of Hepatology. She believes that medical care should be a close collaboration between the physician and the patient. She enjoys caring for patients and creating long-term relationships that benefit their health.

Dr. Larson earned her M.D. from the UW. She is board certified in Gastroenterology and Transplant Hepatology. She is a fellow of the American Association for the Study of Liver Disease, American Gastroenterological Association and the American College of Physicians, and a member of the American Society of Transplantation.

Board Certifications:

  • Transplant Hepatology, 2006, American Board of Internal Medicine
Education & Training: 
Fellowship in Transplant Hepatology
University of Washington
1997
Fellowship in Gastroenterology/Internal Medicine
University of California, San Francisco
1996
Residency in Internal Medicine
University of Washington
1994
Internship in Internal Medicine
University of Washington
1992
Medical Education
University of Washington School of Medicine
1991
Research & Clinical Interests
Clinical Interests: 
  • Hepatology (Liver)
  • Liver Transplant and Evaluation
Publications
Publications: 
Larson AM, Graham MM. Demonstration of Pleural Cerebrospinal Fluid Leak by In-111 DTPA Radionuclide Myelogram. Clin Nucl Med 1992; 17(9):754-755. [PMID: 1395358] [original work]
 
Larson AM, Chan CG, Wartelle CF, McVicar JP, Carithers RL, Hamill GM, Kowdley KV. Infection complicating percutaneous liver biopsy in liver transplant recipients. Hepatology 1997; 26:1406-1409. [PMID: 9397978] [original work]
 
Gaster B, Larson AM. Hepatitis C: Common Questions, Practical Answers. J Am Board Fam Pract 2000; 13:359-363. [PMID: 11001007] [original work]
 
Carr DB, Larson AM, Schmucker BC, Brateng DA, Carithers RL, Easterling TR. Maternal hemodynamics and pregnancy outcome in women with prior orthotopic liver transplantation. Liver Transplantation and Surgery; 2000; 6:213-221. [PMID: 10719023] [original work]
 
Cotler SJ, Wartell CF, Larson AM, Gretch DR, Jensen DM, Carithers RL. Pretreatment symptoms and dosing regimen predict side effects of interferon therapy for hepatitis C. J Viral Hepat 2000 7:211-217. [PMID: 10849263] [original work]
 
Polyak SJ, Nousbaum J-B, Larson AM, Cotler S, Carithers RL, Gretch DR. The PKR-Interacting domain in the Hepatitis C virus second envelope glycoprotein gene is highly conserved in patients treated with interferon. J Infect Dis 2000; 182:397-404. [PMID: 10915068] [original work]
 
Nousbaum JB, Polyak SJ, Ray SC, Sullivan DG, Larson AM, Carithers RL, Gretch DR. Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy. J Virol 2000; 74:9028-9038. [PMID: 10982347] [original work]
 
Dwight MM, Kowdley KV, Russo JE, Ciechanowski, Larson AM, Katon WJ. Depression, fatigue and functional disability in patients with chronic hepatitis C. J Psychosomatic Res 2000; 49:311-317. [PMID: 11164055] [original work]
 
Larson AM, Carithers RL. Hepatitis C in clinical practice. J Intern Med 2001; 249:111-120. [PMID: 11258360] [review]
 
Larson AM. Liver disease in Pregnancy. Clinical Perspectives in Gastroenterology 2001; 4:351-357 [original work]
 
Rajvanshi P, Larson AM, Kowdley KV. Temporary support for acute liver failure: a review. J Clin Gastroenterol 2002; 35(4):335-344. [PMID: 12352298] [review]
 
Ostapowicz G, Fontana RJ, Schiødt FV, Larson AM, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002; 137:947-954. [PMID: 12484709] [original work]
 
Larson AM. Liver Disease in Hemorrhagic Hereditary Telangiectasia. J Clin Gastroenterol 2003; 36:149-158. [PMID: 12544200] [review]
 
Beymer C, Kowdley KV Larson AM, Edmonson P, Dellinger EP, Flum DR. Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass. Arch Surg 2003; 138:1240-1244. [PMID: 14609874] [original work]
 
Larson AM, Taylor SL, Bauermeister D, Rosoff L, Kowdley KV. Pilot study of the relationship between histologic progression and hepatic iron concentration in chronic hepatitis C. J Clin Gastroenterol 2003; 37:406-411. [PMID: 14564190] [original work]
 
Hebert MF, Park JM, Chen YL, Akhtar S, Larson AM. Effects of St. John’s wort (Hypericum perforatum) on tacrolimus pharmacokinetics in healthy volunteers. J Clin Pharmacol 2004; 44:89-94. [PMID: 14681346] [original work]
 
Schwartz JM, Beymer C, Althaus SJ, Larson AM, Zaman A, Glickerman DJ, Kowdley KV. Cardiopulmonary consequences of transjugular intrahepatic portosystemic shunts: role of increased pulmonary artery pressure. J Clin Gastroenterol 2004; 38:590-594. [PMID: 15232363] [original work]
 
Murray KF, Finn LS, Taylor SL, Seidel KD, Larson AM A Comparison of Liver Histology and Alanine Aminotransferase levels in Children and Adults with Chronic Hepatitis C. J Pediatr Gastroenterol Nutr 2005; 41(5):634-638. [PMID: 16254522] [original work]
 
*Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiodt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-Induced Acute Liver Failure: Results of a United States Multicenter, Prospective Study. Hepatology 2005; 42:1364-1372. [PMID: 16317692] [original work]
 
Larson AM. The Epidemiology of Hepatocellular Carcinoma in the Setting of Hepatitis C Virus Infection. Current Hep Reports 2005; 4:145-152 [review]
 
Vaquero J, Fontana RJ, Larson AM, Bass NM, Davern TJ, Shakil AO, Han S, Harrison ME, Stravitz RT, Lee WM, and Blei AT. Complications and use of Intracranial Pressure Monitoring in Patients with Acute Liver Failure and Severe Encephalopathy. Liver Transplantation 2005; 11:1581-1589. [PMID: 16315300] [original work]
 
*Yeh MM, Larson AM, Tung BY, Swanson PE, Upton MP. Endotheliitis in Chronic Liver Disease: A Common Finding. Am J Surg Pathol 2006 30:727-733. [PMID: 16723850] [original work]
 
Davern TJ, James L, Hinson J, Polson J, Larson AM, Fontana RJ, Lee, WM. Measurement of Serum Acetaminophen Protein Adducts in Patients with Acute Liver Failure. Gastroenterology 2006; 130:687-694. [PMID: 16530510] [original work]
 
Larson AM, Curtis JR. Integrating Palliative Care and Transplantation: “Too Well for Transplant, Too Sick for Life”. JAMA 2006 295:2168-2176. [PMID: 16684988] [Review]
 
Taylor RM, Davern T, Munoz S, Han SH, McGuire B, Larson AM, Hynan L, Lee WM, Fontana RJ. Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes. Hepatology 2006; 44:1589-97. [PMID: 17133489] [original work]
 
*Yeh MM, Larson AM, Campbell JS, Fausto N, Rulyak SJ, Swanson PE. The Expression of Transforming Growth Factor-alpha in Cirrhosis, Dysplastic Nodules, and Hepatocellular Carcinoma: An Immunohistochemical Study of 70 cases. Am J Surg Pathol. 2007 May;31(5):681-689. [PMID: 16723850] [original work]
 
Chan EY, Larson AM, Gernsheimer TB, Kowdley KV, Carithers RL, Reyes JD, Perkins JD. Recipient and Donor Factors Influence the Incidence of Graft-versus-Host Disease in Liver Transplant Patients. Liver Transpl. 2007 Apr;13(4):516-22. [PMID: 17394149] [original work]
 
Ko CW, Riffle S, Shapiro JA, Saunders MD, Lee SD, Tung BY, Kuver R, Larson AM, Kowdley KV, Kimmey MB. Incidence of minor complications and time lost from normal activities after screening or surveillance colonoscopy. Gastrointest Endosc 2007 65:648-656. [PMID: 17173914] [original work]
 
Parekh NK, Hynan LS, De Lemos J, Lee WM, Polson J, Pezzie C, Lalani E, Reisch JS, Larson AM, Do H, et al. Elevated troponin I levels in acute liver failure: Is myocardial injury an integral part of acute liver failure. Hepatology 2007 45(6):1489-1495. [PMID: 17538968] [original work]
 
Larson AM. Acetaminophen Hepatotoxicity. Clin Liver Dis. 2007 Aug;11(3):525-48, vi. [PMID: 17723918] [Review]
 
Diamond DL, Jacobs JM, Paeper B, Proll SC, Gritsenko MA, Carithers RL Jr, Larson AM, Yeh MM, Camp DG 2nd Smith RD, Katze MG. Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Hepatology. 2007 Sep;46(3):649-57. [PMID: 17654742] [original work]
 
Chan EY, Olson LC, Kisthard JA, Perkins JD, Bakthavatsalam R, Halldorson JB, Reyes JD, Larson AM, Levy AE. Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors. Liver Transpl 2008 May;14(5):604-10. [PMID: 18433032] [original work]
 
Liou IW, Larson AM. Role of liver transplantation in acute liver failure. Semin Liver Dis. 2008 May;28(2):201-9. [PMID: 18452119] [Review]
 
Chan EY, Larson AM, Fix OK, Yeh MM, Levy AE, Bakthavatsalam R, Halldorson, JB, Reyes, JD, Perkins, JD. Identifying risk for recurrent hepatocellular carcinoma after liver transplantation: implications for surveillance studies and new adjuvant therapies. Liver Transpl 2008; 14:956-965. [PMID: 18581511] [original work]
 
Larson AM. Acute Liver Failure. Dis Mon 2008; 54:457-485. [PMID: 18570915] [Review]
 
Lee WM, Larson AM, Arenas J. Thinking through acetaminophen hepatotoxicity and liver transplantation: choosing worth recipients. Liver Transpl 2009; 15:567-569. [PMID: 19479797] [Review]
 
*Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage nonacetaminophen acute liver failure. Gastroenterology 2009; 137:856-864. [PMID: 19524577] [original work]
 
Larson AM. Diagnosis and management of acute liver failure. Curr Opin Gastroenterol 2010; 26:214-221. [PMID: 20216412] [Review]
 
Gregory B, Larson AM, Reisch J, Lee WM. Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure. J Investig Med 2010; 58:707-710. [PMID: 20305573] [original work]
 
Khandelwal N, James LP, Sanders C, Larson AM, Lee WM. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology 2011; 53(2):567-576. [PMID: 21274877] [original work]
 
Alqahtani SA, Larson AM. Adult liver transplantation in the USA. Curr Opin Gastroenterol 2011; 27(3):240-247 [PMID: 21378559] [Review]
 
Lee WM, Stravitz RT, Larson AM. Introduction to the revised American Association for the Study of Liver Diseases position paper on acute liver failure 2011. Hepatology 2011; 55 (3):965-967. [PMID: 22213561] [Practice Guideline]
 
Diamond DL, Krasnoselsky AL, Burnum KE, Monroe ME, Webb-Robertson BJ, McDermott JE, Yeh MM, Golib Dzib JF, Susnow N, Strom S, Proll SC, Belisle SE, Purdy DE, Rasmussen AL, Walters KA, Jacobs JM, Gritsenko MA, Camp DG, Bhattacharya R, Perkins JD, Carithers RL Jr, Liou IW, Larson AM, Benecke A, Waters KM, Smith RD, Katze MG. Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus mediated liver disease post-transplantation. Hepatology 2012; 56(1):28-38. [PMID 22331615] [original work]
 
Rasmussen AL, Tchitchek N, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers RL, Benecke A, Katze MG. Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients. Hepatology 2012; 56(1):17-20. [PMID: 22278598] [original work]
 
Bachir N, Larson AM. Adult Liver Transplantation in the United States. Am J Med Sci 2012; 343(6):462-469. [PMID: 22683615] [Review]
February 2, 2021
 
Pant C, Deshpande A, Larson AM, O’Connor J, Rolston DDK, Sferra T, Deshpande A. Diarrhea in Solid-Organ Transplant Recipients: A review of the evidence. Current Medical Research and Opinion 2013; 29(10):1315-1328. [PMID: 23777312] [Review]
 
Tujios SR, Hynan LS, Vazquez MA, Larson AM, et al. Risk factors and outcomes of acute kidney injury in patients with acute liver failure. Clin Gastroenterol Hepatol 2014; 13(2):352-359 [PMID: 25019700] [original work]
 
Larson AM. Liver disease and its treatment. Preface. Med Clin North Am 2014; 98(1):xv-xvi. [PMID: 24266921] [Review]
 
Larson AM. Palliative care for patients with end-stage liver disease. Curr Gastroenterol Rep 2015; 17(5):440 [PMID: 25855211] [Review]
 
*Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Smith A, Brown R, Crippin J, Harrison ME, Koch D, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hassanein T, Hanje AJ, Olson J, Subramanian R, Karvellas C, Hameed B, Sherker AH, Robuck P, Lee WM Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study. Ann Int Med 2016; 164(11):724 [PMID: 27043883] [original work]
 
Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A. The Natural History of Severe Acute Liver Failure. Am J Gastroenterol 2017; 2071; 112:1389-1396 [PMID: 28440304] [original work]
 
Granger DR, Rule J, Rakela J, Bass N, Reuben A, Stravitz RT, Sussman N, Larson AM, James L, Chiu C, Lee WM. Acute liver failure of indeterminate etiology: A comprehensive systematic approach by an expert committee to establish causality. Am J Gastroenterol 2018; 113:1319-1328 [PMID: 29946176] [original work]
 
Cannon CA, Corcorran MA, Shaw KW, Montenovo M, Sibulesky L, Reyes JD, Rayhill SC, Larson AM, Kritek PA, Giovanni S, de Castro I, Arora N, Rakita RM. Hyperammonemia syndrome due to Ureplasma infection after liver-kidney transplant. Transpl Infect Dis 2020; 22(3):e13298 [PMID: 32306488] [original work]
 
MacDonald AJ, Speiser JL, Ganger DR, Nilles KM, Orandi BJ, Larson AM, Lee WM, Karvellas CJ for the US ALFSG. Clinical and neurological outcomes in acetaminophen-induced acute liver failure: a twenty-one-year multicenter cohort study. Clin Gastroenterol Hepatol 2020:S1542-3565(20)31273-8 [PMID: 32920216] [original work]