David M. Hockenbery
Professor
Medicine
Division of Gastroenterology
Head, Gastroenterology & Hepatology Section
Member, Fred Hutchinson Cancer Research Center
Seattle Cancer Care Alliance

Faculty Information

Biography

Members of Dr. Hockenbery's laboratory study the genetic and biochemical mechanisms of programmed cell death, or apoptosis, in a variety of experimental systems. Normal cell death occurring during development and following terminal differentiation has typical morphologic and biochemical features collectively termed apoptosis. The precise control of these events is obviously of great importance to the organism and many model systems have demonstrated the requirement for active RNA and protein synthesis for cell death to proceed, suggesting an internally programmed process. One regulator of this process is the bcl-2 oncogene, which blocks apoptosis in vitro and in vivo and appears to normally control the timing of cell death in many cell lineages.

Board Certifications:

  • Gastroenterology, 1989, American Board of Internal Medicine
  • Internal Medicine, 1985, American Board of Internal Medicine
Education & Training: 
Teaching Appointment
University of Washington
2012
Fellowship in Gastroenterology/Hepatology
Washington University School of Medicine
1992
Residency in Internal Medicine
Johns Hopkins University School of Medicine
1986
Internship in Internal Medicine
Johns Hopkins University School of Medicine
1985
Medical Education
Washington University School of Medicine
1982
Research & Clinical Interests
Clinical Interests: 
  • Gastroenterology (Digestive)
  • Internal Medicine
Publications
Publications: 
Colello GD, Hockenbery DM, Bosmann HB, Fuchs S, Folkers K: Competitive inhibition of benzodiazepine binding by fractions from porcine brain. Proc. Natl. Acad. Sci. USA 75:6319-6323, 1978. PMCID: PMC393173
 
Lock DR, Hockenbery DM, Cunningham J, Hahm KS, Kantor O, Schonfeld G: Apolipoprotein B subspecies in chylomicrons isolated from a patient with chyluria. Am. J. Med. 75:360-363, 1983. PMID: 6860422
 
Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ: Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor deprived hematopoietic cell lines. J. Immunol. 144:3602-3610, 1990. PMID: 2184193
 
McDonnell TJ, Nunez G, Platt FM, Hockenbery D, London L, McKearn JP, Korsmeyer SJ: Deregulated Bcl-2-Ig transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol. Cell. Biol. 10:1901-1907, 1990. PMCID: PMC360535
 
Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2, an inner mitochondrial membrane protein, blocks programmed cell death. Nature 348: 334-336, 1990. PMID: 2250705
 
Hockenbery DM, Zutter M, Hickey W, Korsmeyer SJ: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci.USA 88, 6961-6965, 1991. PMCID: PMC52213
 
Zutter M, Hockenbery DM, Silverman GA, Korsmeyer SJ: Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms. Blood 78: 1062-1078, 1991. PMID: 1868240
 
Nunez G, Hockenbery D, McDonnell TJ, Sorensen C, Korsmeyer SJ: Bcl-2 maintains B cell memory. Nature 353: 71-73, 1991. PMID: 1908951
 
Sentman C, Shutter J, Hockenbery D, Kanagawa O, Korsmeyer SJ: Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888, 1991. PMID: 1835668
 
Clouse RE, Alpers DH, Hockenbery DM, DeSchryver-Kecskemeti K. Pericrypt eosinophilic enterocolitis and chronic diarrhea. Gastroenterology 103(1); 168-76, 1992. PMID: 1612324
 
Rao L, Debras M, Sabbatini P, Hockenbery D, Korsmeyer S, White E: The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA 89: 7742-7746, 1992. PMCID: PMC49787
 
Walton, MI, Whysong, D, O'Connor, PM, Hockenbery D, Korsmeyer, SJ, Kohn, KW: Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Canc. Res. 53: 1853-1861, 1993. PMID: 8467505
 
Hockenbery DM, Oltvai ZN, Yin X-M, Milliman CM, Korsmeyer SJ: Bcl-2 functions in an anti-oxidant pathway to prevent apoptosis. Cell 75: 241-251, 1993. PMID: 7503812
 
 
Liang XH, Mungal S, Ayscue A, Meissner J, Wodnicki P, Hockenbery D, Lockett S, Herman B: Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J. Cell Bio. 57: 509-521, 1995. PMID: 7768985
 
Park JR, Bernstein ID, Hockenbery DM: Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood 86: 868-876, 1995. PMID: 7542499
 
Baehr PH, Levine DS, Bouvier ME, Hockenbery DM, Gooley TA, Stern JG, Martin PJ, McDonald GB: Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. Transplantation. 60: 1231-1238, 1995. PMID: 8525516
 
Vowells SJ, Sekhsaria S, Malech HL, Shalit M, Fieisher TA. Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes. Immunological Methods. 1995; 178 (1):89-97. PMID: 7829869.
 
Karasavvas N, Erukuila RK, Bittman R, Lockshin R, Hockenbery D, Zakeri Z. BCL-2 suppresses ceramid-induced cell killing. Cell Death and Differentiation. 1996; 3(1): 149-51. PMID: 17180067.
 
Hong DS, Beckman C, Huss R, Lee JW, Hockenbery D, Ledbetter J, Deeg J: Major histocompatibility complex class II-mediated inhibition of hematopoiesis in long-term marrow cultures involves apoptosis and is prevented by c-kit ligand. Blood 86: 3341-3352, 1996. PMID: 7579437
 
Anderson BO, Nasab M, Mancini M, Tam A, Hockenbery D. Herbimycin induces apoptotic cell death in breast cancer by causing mitochondrial replication to dissociate from cell cycle. Breast Cancer Res Treat 41: 280, 1996.
 
Hirose K, Hockenbery DM, and Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hearing Research 104: 1-14, 1997. PMID: 9119753
 
Tzung S-P, Fausto N, and Hockenbery D. Expression of bcl-2 family during murine liver regeneration and identification of bcl-x as a delayed early response gene. Am. J. Pathol. 150: 1985-1995, 1997. PMCID: PMC1858315
 
Mancini M, Anderson BO, Caldwell E, Sedghinasab M, Paty PB, Hockenbery D. Mitochondrial proliferation and paradoxical membrane depolarization during Herbimycin A-induced terminal differentiation and apoptosis in a human colon carcinoma cell line. J Cell Biol 138: 449-469, 1997. PMCID: PMC2138196
 
Shankland SJ, Floege J, Thomas SE, Nangaku M, Hugo C, Pippin J, Henne K, Hockenbery DM, Johnson RJ, Couser WG. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: potential role in limiting glomerular epithelial cell proliferation in vivo. Kidney Int 52: 404-413, 1997. PMID: 9263996
 
Robertson KA, Hill DP, Xu Y, Liu L, Van Epps S, Hockenbery DM, Park JR, Wilson TM, Kelley MR. Down regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth Diff 8: 443-9, 1997. PMID: 9101090
 
Camilleri-Broet S, Vanderwerff H, Caldwell E, Hockenbery D. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Exp Cell Research 239: 277-292, 1998. PMID: 9521845
 
Mancini M, Sedghinasab M, Knowlton K, Tam A, Hockenbery D. Flow cytometric measurement of mitochondrial mass and function: a novel method for assessing chemoresistance:. Ann. Surg. Oncol., 5, 287-295, 1998. PMID: 9607633
 
Tzung S-P, Hackman RC, Hockenbery DM, Bensinger W, Schiffman K, McDonald GB. Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic stem cell transplantation. Biology of Blood ad Marrow Transplantation 4: 43-48, 1998. PMID: 9701391
 
Knowlton K, Mancini M, Creason S, Morales C, Hockenbery D, Anderson BO. Bcl-2 slows in vitro breast cancer growth despite its apoptotic effect. J Surg Res 76:22-26, 1998. PMID: 9695733
 
McDonald GB, Bouvier M, Hockenbery DM, Stern JM, Gooley T, Farrand A, Murakami C, Levine DS. Oral beclomethasone dipropionate for treatment of intestinal graft-vs.-host disease: A randomized, placebo-controlled trial. Gastroenterology 115: 28-35, 1998. PMID: 9649455
 
Wu D, Hockenbery DM, Baehr PH, Ponec RJ, Brentnall T, Kuver RP, Tzung S-P, Kim SU, Kim KA, Malik R, Joe RW, Shimoda NT, Todaro JL, McDonald GB. Persistent nausea and anorexia in marrow transplant patients: A prospective study of 78 patients. Transplantation 66: 1319-1324, 1998. PMID: 9846516
 
 
Wright ME, Han DK, Carter L, Fields S, Schwartz SM, Hockenbery DM. Caspase-3 inhibits growth in Saccharomyces cerevisiae without causing cell death. FEBS Lett.446: 91-4, 1999. PMID: 10100604
 
Wright ME, Han DK, Hockenbery DM. Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells. FEBS Lett 481: 13-18, 2000. PMID: 10984607
 
Welters CF, Piersma FE, Hockenbery DM, Heineman E. The role of apoptosis during intestinal adaptation after small bowel resection. J Pediatr Surg 35:20-4, 2000. PMID: 10646767
 
Tzung S-P, Kim K, Basanez G, Giedt C, Simon J, Zimmerberg J, Zhang K, Hockenbery DM. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nature Cell Biol. 3, 183-191, 2001. PMID: 11175751
 
Schwartz JM, Wolford JL, Thornquist MD, Hockenbery DM, Murakami CS, Drennan F, Hinds M, Strasser SI, Lopez-Cubero SO, Brar HS, Ko CW, Saunders MD, Okolo CN, McDonald GB. Severe gastrointestinal bleeding after hematopoietic cell transplantation, 1987-1997: incidence, causes, and outcome. Am J Gastroenterol 96: 385-93, 2001. PMID: 11232680
 
Kim KM, Giedt CD, Basanez G, O’Neill JW, Hill JJ, Han YH, Tzung SP, Zimmerberg J, Hockenbery DM, Zhang KY. Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A. Biochem 40: 4911-4922, 2001. PMID: 11305906
 
Seewaldt VL, Mrozek K, Sigle R, Dietze EC, Heine K, Hockenbery DM, Hobbs KB, Caldwell LE. Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosis. J. Cell. Biol. 155: 471-86, 2001. PMCID: PMC2150841
 
Morrish F, Giedt C, Hockenbery DM. c-MYC apoptotic function is mediated by NRF-1 target genes. Genes and Development, 17:240-255, 2003. PMCID: PMC195978
 
Haughn L, Hawley RG, Morrison DK, Hockenbery DM. Bcl-2 and Bcl-xL determine bipolar lineage choice by their differential influence on the expression of cRaf1. J Biol Chem, 278: 25158, 2003. PMID: 12721288
 
Pinto-Marques P, Hockenbery DM, Hackman RC, Tapper D, McDonald GB. Successful medical treatment of intestinal ulceration caused by Rhizopus microsporus. Bone Marrow Transplantation 32: 739-40, 2003. PMID: 13130324
 
Wright ME, Eng J, Sherman J, Hockenbery DM, Nelson PS, Galitski T, Aebersold R. Identification of androgen co-regulated protein networks in prostate cancer cells. Genome Biol. 5: R4, 2003. PMCID: PMC395736
 
Manion MK, O’Neill JW, Giedt CD, Kim KM, Zhang KYJ, Hockenbery DM. Bcl-xL mutations suppress cellular sensitivity to antimycin A. J Biol Chem 279: 2159-2165, 2004. PMID: 14534311
 
Lesnikov, VA, Lesnikova MP, Shulman HM, Wilson HM, Hockenbery DM, Kocher M, Pierpaoli W, Deeg HJ. Prevention of Fas-mediated hepatic failure with transferrin. Lab Invest. 84: 342-52, 2004. PMID: 14704719
 
Erxleben HA, Manion MK, Hockenbery DM, Scampavia L, Ruzicka J. A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system. Analyst 129: 205-212, 2004. PMID: 14978521
 
Perry ME, Dang CV, Hockenbery D, Moll U. Highlights of the National Cancer Institute workshop on mitochondrial function and cancer. Cancer Res 64: 7640-7644, 2004. PMID: 15492294
 
 
Ho HK, Hu ZH, Tzung SP, Hockenbery DM, Fausto N, Nelson SD, Bruschi SA. BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death. Biochemical Pharmacology. 69 (1): 147-57, Jan. 2005. PMID: 15588723
 
Wang H, Li M, Rhie JK, Hockenbery DM, Covey JM, Zhang R, Hill DL. Preclinical pharmacology of 2-methoxyantimycin A compounds as novel antitumor agents. Cancer Chem Pharm, 56 (3):291-8, 2005. PMID: 15883820
 
Pagel JM, Laugen C, Bonham L, Hackman RC, Hockenbery DM, Bhatt R, Hollenback D, Carew H, Singer JW, Press OW. Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin’s lymphomas. Clin Cancer Res, 11 (13):4857-66, 2005. PMID: 16000584
 
O'Neill JW, Manion MK, Maguire B, Hockenbery DM. BCL-XL dimerization by three-dimensional domain swapping. J Mol Biol 356:367-81, 2006. PMID: 16368107. DOI: 10.1016/j.jmb.2005.11.032
 
Holmberg L, Kikuchi K, Gooley TA, Adams KM, Hockenbery DM, Flowers ME, Schoch HG, Bensinger W, McDonald GB. Gastrointestinal graft-versus-host disease in recipients of autologous hematopoietic stem cells: incidence, risk factors, and outcome Biol Blood Marrow Transplant 12: 226-34, 2006. PMID: 16443520. DOI: 10.1016/j.bbmt.2005.10.011
 
Selinger RR, McDonald GB, Hockenbery DM, Steinbach G, Kimmey MB. Efficacy of neodymium:YAG laser therapy for gastric antral vascular ectasia (GAVE) following hematopoietic cell transplant. Bone Marrow Transplant 37:191-7, 2006. PMID: 16284614. DOI: 10.1038/sj.bmt.1705212
 
Hockenbery DM. MMPs in unusual places Am J Pathol 169:1101-3, 2006. PMID: 17003469. PMCID: PMC1780248
 
Morrish F, Buroker NE, Ge M, Ning XH, Lopez-Guisa J, Hockenbery D, Portman MA. Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA. Mitochondrion6(3):143-8, 2006. PMID: 16730242. DOI: 10.1016/j.mito.2006.04.002
 
Hockenbery DM, Cruikshank S, Rodell TC, Gooley T, Schuening F, Rowley S, David D, Brunvand M, Berryman B, Abhyankar S, Bouvier M, McDonald GB. A randomized, placebo-controlled trial of oral beclomethasome dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host-disease. Blood 109: 4557-63, 2007. PMID: 17244684. DOI: 10.1182/blood-2006-05-021139
 
Ying SX, Seal S, Abbassi N, Hockenbery DM, Kiem HP, Li X, Pagel JM, Gopal AK, Deeg HJ. Differential effects of bexarotene on intrinsic and extrinsic pathways in TRAIL-induced apoptosis in two myeloid leukemia cell lines. Leuk Lymphoma 48: 1003-14, 2007. PMID: 17487744
 
Phelps RA, Gingras H, Hockenbery DM. Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA crosslinking. Exp Cell Res 313: 2283-92, 2007. PMID: 17490643
 
Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM. 2-methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition. Mol Cancer Ther, 6:2073-80, 2007. PMID: 17620436
 
Margineantu DH, Emerson CB, Diaz D, Hockenbery DM. Hsp90 inhibition decreases mitochondrial protein turnover. PLoS One 2:e1066, 2007. PMCID: PMC2031825
 
Morrish F, Neretti N, Sedivy JM, Hockenbery DM. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle 7:1054-66, 2008. PMCID: PMC2518168
 
 
Stirewalt DL, Meshinchi S, Kopecky KJ, Fan W, Pogosova-Agadjanyan EL, Engle JH, Cronk MR, Dorcy KS, McQuary AR, Hockenbery D, Wood B, Heimfeld S, Radich JP. Identification of genes with abnormal expression changes in acute myeloid leukemia. Genes Chromos Cancer 47:8-20, 2008. PMID: 17910043. DOI: 10.1002/gcc.20500
 
Seal S. Hockenbery DM. Spaulding EY. Kiem HP. Abbassi N. Deeg HJ. Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals. Exp Hem 36:1660-72, 2008. PMCID: PMC2645417.
 
Sweet IR, Gilbert M, Maloney E. Hockenbery D, Schwartz M, Kim F. Endothelial inflammation induced by excess glucose is associated with cytosolic glucose-6-phosphate but not increased mitochondrial respiration. Diabetologia 52:921-31, 2009. PMCID: PMC2741088.
 
Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery DM. C-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 28:2485-91, 2009. PMCID: PMC2779836.
 
Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F. Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arteriosclerosis, Thrombosis & Vascular Biology 29:1370-5, 2009. PMCID: PMC2775080.
 
Brinkkoetter PT, Olivier P, Henderson S, Krofft RD, Pippin JW, Hockenbery D, Roberts JM, Shankland SJ. Cyclin I, a novel activator of CDK5, regulates expression of Bcl-2 and Bcl-xL in post-mitotic cells. J Clin Invest 119(10):3089-01, 2009. PMCID: PMC2752065.
 
Delgado T, Carroll PA, Punjabi AS, Margineantu D, Hockenbery DM, Lagunoff M. Induction of the Warburg effect by Kaposi’s sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci USA 107(23):10696-701, 2010. PMCID: PMC2890792.
 
*Morrish F, Noonan J, Perez-Olsen C, Gafken PR, Fitzgibbon M, Kelleher J, Van Gilst M, Hockenbery D. Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry. J Biol Chem 285:36267-74, 2010. PMCID: PMC2978554
 
Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, McDonald GB. Blood and gastric FOXp3+ T cells are not decreased in human gastric graft vs host disease. Biol Blood Marrow Transplant 17:486-96, 2011. PMCID: PMC3026868
 
Jung SR, Kuok IT, Couron D, Rizzo N, Margineantu DH, Hockenbery DM, Kim F, Sweet IR. Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets. J Biol Chem 286:17422-34, 2011. PMCID: PMC3093816
 
May D. Pan S. Crispin DA. Lai K. Bronner MP. Hogan J. Hockenbery DM. McIntosh M. Brentnall TA. Chen R. Investigating neoplastic progression of ulcerative colitis with label-free comparative proteomics. J Proteome Res. 10(1):200-9, 2011. PMCID: PMC3017661
 
Park H, Staehling K, Tsang M, Appleby MW, Brunkow ME, Margineantu D, Hockenbery DM, Habib T, Liggitt HD, Carlson G, Iritani BM. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Immunity. 36(5):769-81, 2012. PMCID: PMC3361584.
 
Zhou W, Choi M, Margineantu D, Margaretha L, Hesson J, Cavanaugh C, Blau CA, Horwitz MS, Hockenbery D, Ware C, Ruohola-Baker H. HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J 31(9):2103-16, 2012. PMCID: PMC3343469.
 
Suchorolski MT, Paulson TG, Sanchez CA, Hockenbery DM, Reid BJ. Warburg and Crabtree effects in premalignant Barrett’s esophagus cell lines with active mitochondria. PLoS One, 8:e56884, 2013. PMCID: PMC3584058
 
Procko E, Berguig GY, Shen BW, Song Y, Frayo S, Convertine AJ, Margineantu D, Booth G, Correia BE, Cheng Y, Schief WR, Hockenbery DM, Press OW, Stoddard BL, Stayton PS, Baker D. A computationallyy designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells. Cell 157: 1644-56, 2014. PMCID: PMC4079535
 
Hockenbery, DM. Forecast: Rough Seas for Leukemia. Cancer Discovery 4:278-279, 2014. PMID: 24596202. DOI: 10.1158/2159-8290.CD-14-0084
 
Marcondes AM, Karoopongse E, Lesnikova M, Margineantu D, Welte T, Dinarello CA, Hockenbery D, Janciauskiene S, Deeg HJ. α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics. Blood 124:2881-91, 2014. PMCID: PMC4215316.
 
Reyes NL, Banks GB, Tsang M, Margineantu D, Gu H, Djukovic D, Chan J, Torres M, Liggitt HD, Hirenallur-S DK, Hockenbery DM, Raftery D, Iritani BM. Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Proc Natl Acad Sci U S A. 112:424-9, 2015. doi: 10.1073/pnas.1413021112. PMCID: PMC4299192.
 
Evans AT, Loeb KR, Shulman HM, Hassan S, Qiu WC, Hockenbery DM, Ioannou GN, Chauncey TR, Gretch DR, McDonald GB. Fibrosing cholestatic hepatitis C after hematopoietic cell transplantation: report of 3 fatal cases. Am J Surg Pathol. 39:212-20, 2015. PMID: 25517948. DOI: 10.1097/PAS.0000000000000345
 
Berguig GY, Convertine AJ, Frayo S, Kern HB, Procko E, Roy D, Srinivasan S, Margineantu DH, Booth G, Palanca-Wessels MC, Baker D, Hockenbery D, Press OW, Stayton PS. An intracellular delivery system for antibody-peptide drug conjugates. Mol Ther. 23:907-17, 2015. doi: 10.1038/mt.2015.22., 2015. PMCID: PMC4427876
 
Gamble LJ, Graham DJ, Bluesteine B, Whitehead NP, Hockenbery D, Morrish F, Porter P. ToF-SIMS of tissues: “lessons learned” from mice and women. Biointerphases 10:09008, 2015. PMCID: PMC4327923
 
Robinson MA, Graham DJ, Morrish F, Hockenbery D, Gamble LJ. Lipid analysis of eight human breast cancer cell lines with ToF-SIMS. Biointerphases 11:02A303, 2015. PMCID: PMC4552699
 
*Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margonlin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H. The metabolome regulates the epigenetic landscape during naïve-to-primed human embryonic stem cell transition. Nat Cell Biol 17:1523-35, 2015. PMCID: PMC4662931
 
Bluestein BM, Morrish F, Hockenbery DM, Gamble LJ. An investigation of the pancreatic islet tumor microenvironment with Time-of-Flight Secondary Ion Mass Spectrometry. Microscopy and microanalysis. 2015; 21(Suppl 3): 2065-2066. DOI: https://doi.org/10.1017/S1431927615011101
 
Bluestein BM, Morrish F, Graham DJ, Guenthoer J, Hockenbery D, Porter PL, Gamble LJ. An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS. Analyst. 2016; 141(6); 1947-57. PMID: 26878076. PMCID: PMC4783233
 
Marcondes AM, Hockenbery D, Lesnikova M, Dinarello CA, Woolfrey A, Gernsheimer T, Loghman-Adham M, Gelmont D, Storer B, Hansen JA, Deeg HJ. Response of Steroid-Refractory Acute GVHD to α1-Antitrypsin. Biol Blood Marrow Transplant. 2016; 22(9); 1596-601. PMID: 27223109. DOI: 10.1016/j.bbmt.2016.05.011
 
*Berger S, Procko E, Margineantu D, Lee EF, Shen BW, Zelter A, Silva DA, Chawla K, Herold MJ, Garnier JM, Johnson R, MacCoss MJ, Lessene G, Davis TN, Stayton PS, Stoddard BL, Fairlie WD, Hockenbery DM, Baker D. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife. 2016 Nov 2;5. doi: 10.7554/eLife.20352. PubMed PMID: 27805565; PubMed Central PMCID: PMC5127641.
 
Iwata TN, Ramírez JA, Tsang M, Park H, Margineantu DH, Hockenbery DM, Iritani BM. Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism. J Immunol. 2016 Sep 15;197(6):2250-60. doi: 10.4049/jimmunol.1600492. Epub 2016 Aug 12. PubMed PMID: 27521345; PubMed Central PMCID: PMC5009877.
 
Aguilar E, Marin de Mas I, Zodda E, Marin S, Morrish F, Selivanov V, Meca-Cortés Ó, Delowar H, Pons M, Izquierdo I, Celià-Terrassa T, de Atauri P, Centelles JJ, Hockenbery D, Thomson TM, Cascante M. Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program. Stem Cells. 2016 May;34(5):1163-76. doi: 10.1002/stem.2286. Epub 2016 Feb 2. PubMed PMID: 27146024; PubMed Central PMCID: PMC4860823.
 
Kern HB, Srinivasan S, Convertine AJ, Hockenbery D, Press OW, Stayton PS. Enzyme-Cleavable Polymeric Micelles for the Intracellular De-livery of Pro-Apoptotic Peptides. Mol Pharm. 2017; Mar 9. PMID: 28277671. PMCID: PMC5823688.
 
Steinbach G, Hockenbery DM, Huls G, Furlong T, Myerson D, Loeb KR, Fann JR, Castilla-Llorente C, McDonald GB, Martin PJ. Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease. PLoS One. 2017 Aug 17;12(8): e0183284. PMID: 28717727. PMCID: PMC5493242.
 
*Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, Hockenbery D, Houghton AM, Holland EC. Mutant IDH1 regulates the tumor-associated immune system in gliomas. Genes Dev. 2017 Apr 15;31(8):774-786. PMID: 28465358. PMCID: PMC5435890.
 
Steinbach G, Hockenbery DM, Huls G, Furlong T, Myerson D, Loeb KR, Fann JR, Castilla-Llorente C, McDonald GB, Martin PJ. Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease. PLoS One. 2017;12(8):e0183284. doi: 10.1371/journal.pone.0183284. eCollection 2017. PubMed PMID: 28817727; PubMed Central PMCID: PMC5560707.
 
Hickson SE, Margineantu D, Hockenbery DM, Simon JA, Geballe AP. Inhibition of vaccinia virus replication by nitazoxanide. Virology. 2018 May; 518: 398-405. PMID: 29625403. PMCID: PMC5929478.
 
Nagana Gowda GA, Barding GA Jr, Dai J, Gu H, Margineantu DH, Hockenbery DM, Raftery D. A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines. Front Mol Biosci. 2018 May; 15; 5:49. PMID: 29868609. PMCID: PMC5962734.
 
*Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism. Proc Natl Acad Sci U.S.A. 2018 May 22;115(21):5462-5467. PMID: 29735700. PMCID: PMC6003503
 
Centini R, Tsang M, Iwata T, Park H, Delrow J, Margineantu D, Iritani BM, Gu H, Liggitt HD, Kang J, Kang L, Hockenbery DM, Raftery D, Iritani BM. Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. PLoS One. 2018 Jun 13;13(6): e0197973. PMID: 29897930. PMCID: PMC5999084.
 
Bluestein BM, Morrish F, Graham DJ, Huang L, Hockenbery D, Gamble LJ. Analysis of the Myc-induced pancreatic β cell islet tumor microenvironment using imaging ToF-SIMS. Biointerphases. 2018 Aug 28;13(6):06D402. PMID: 30153736. PMCID: PMC6113053.
 
Yeung CC, Hockenbery DM, Westerhoff M, Coutre SE, Sedlak RH, Dubowy RL, Munugalavadla V, Taylor K, Bosch F. Pathological assessment of gastrointestinal biopsies from patients with idelalisib-associated diarrhea and colitis. Future Oncol. 2018 Sep; 14(22):2265-2277. PMID: 29569483. DOI: 10.2217/fon-2017-0528
 
Lampe JW, Kim E, Levy L, Davidson LA, Goldsby JS, Miles FL, Navarro SL, Randolph TW, Zhao N, Ivanov I, Kaz AM, Damman C, Hockenbery DM, Hullar MAJ, Chapkin RS. Colonic mucosal and exfoliome transcriptomic profiling and fecal microbiome response to a flaxseed lignan extract intervention in humans. Am J Clin Nutr 110: 377-390, 2019. PMID: 31175806 PMCID: PMC6669062
 
Margres MJ, Ruiz-Aravena M, Hamede R, Chawla K, Patton AH, Lawrance MF, Fraik AK, Stahlke AR, Davis BW, Ostrander EA, Jones ME, McCallum H, Paddison PJ, Hohenlohe PA, Hockenbery D, Storfer A. Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation. Genetics. 2020 Aug;215(4):1143-1152. doi: 10.1534/genetics.120.303428. Epub 2020 Jun 18. PubMed PMID: 32554701; PubMed Central PMCID: PMC7404226.