Iris W. Liou
Clinical Associate Professor
Medicine
Associate Director, Gastroenterology Fellowship Program
Division of Gastroenterology

Faculty Information

Biography

Iris Liou, M.D., is a board certified physician at the Liver Tumor Clinic at UW Medical Center, a member of the Acute Liver Failure Study Group, a clinical research network funded by the National Institutes of Health and a UW associate professor of Gastroenterology.

Dr. Liou strives to create active partnerships with her patients to achieve the best possible outcomes.

Dr. Liou earned her M.D. at the UW. She is board certified in both Gastroenterology and Transplant Hematology. Her research interests include acute liver failure, hepatitis B, acute on chronic liver failure, complications of cirrhosis, hepatocellular carcinoma and clinical outcomes following liver transplantation.

Board Certifications:

  • Transplant Hepatology, 2008, American Board of Internal Medicine
  • Gastroenterology, 2007, American Board of Internal Medicine
Education & Training: 
Fellowship in Transplant Hepatology
University of Washington
Fellowship in Gastroenterology
University of Washington
Residency in General Internal Medicine
University of Washington
Internship in General Internal Medicine
University of Washington
Medical Education
University of Washington School of Medicine
2000
Research & Clinical Interests
Clinical Interests: 
  • Gastroenterology (Digestive)
  • Liver Transplant and Evaluation
  • Hepatology (Liver)
  • Telehealth Services
Publications
PubMed: 
PubMed Bibliography
Publications: 
Liou I, Kowdley KV. Natural history of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006; 40(S1): S11-16. [review]
 
Ioannou GN, Liou IW, Weiss NS. Serum bilirubin and colorectal cancer risk: a population-based cohort study. Aliment Pharmacol Ther 2006; 23(11): 1637-1642. [original work]
 
Stepan C, Liou I, Surawicz CM. Management of acute infectious diarrhea. J Clin Outcomes Manage 2006; 13(7): 382-391. [review]
 
*Liou IW, Larson AM. Role of transplantation in acute liver failure. Semin Liver Dis 2008; 28(2): 201-209.
 
Zeuzem S, Sulkowski MS, Lawitz EJ, Rustgi VK, Rodriguez-Torres M, Bacon BR, Grigorescu M, Tice AD, Lurie Y, Cianciara J, Muir AJ, Cronin PW, Pulkstenis E, Subramanian GM, McHutchinson JG; ACHIEVE-1 Study Team. Albinterferon alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 1. Gastroenterology 2010; 139(4): 1257-1266. [review]
 
Rayhill S, Schwartz J, Ham J, Carithers R, Yu L, Bhattacharya R, Liou I, Landis C, Limaye A, Rakita R, Dick A, Healey P, Halldorson J, Bakthavatsalam R, Perkins J, Reyes J. The use of hepatitis B core antibody-positive donor livers does not appear to have a deleterious effect on graft survival in liver transplantation for hepatitis C. Transplant Proc 2010; 42(10): 4141-4144. [original work]
 
Diamond DL, Krasnoselsky L, Burnum KE, Monroe ME, Webb-Robertson BJ, McDermott JE, Yeh MM, Dzib JF, Susnow N, Strom S, Proll SC, Belisle SE, Purdy DE, Rasmussen AL, Walters KA, Jacobs JM, Critsenko MA, Camp DG, Bhattcharya R, Perkins JD, Carithers RL Jr, Liou IW, Larson AM, Benecke A, Waters KM, Smith RD, Katze MG. Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C-virus medicated liver disease posttransplantation. Hepatology 2012; 56(1): 28-38. [original work]
 
Jia N, Liou I, Halldorson J, Carithers R, Perkins J, Reyes J, Yeh M, Stohr E, Rao S, Lin EH. Phase 1 adjuvant trial of sorafenib in patients with hepatocellular carcinoma after orthotopic liver transplantation. Anticancer Res 2013;33(6);2797-800. [original work]
 
Metushi IG, Sanders C; Acute Liver Failure Study Group, Lee WM, Uetrecht J. Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced acute liver failure. Hepatology 2014; 59(2); 1084-93. [original work]
 
Court MH, Peter I, Hazarika S, Vasiadi M, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. Drug Metab Dispos 2014; 42(1): 28-32. [original work]
 
*Liou IW. Management of end-stage liver disease. Med Clin North Am 2014; 98(1): 119-52. [review]
 
Karvellas CJ, Fix OK, Battenhouse H, Durkalski V, Sanders C, Lee WM; US Acute Liver Failure Study Group. Outcomes and cmplications of intracranial pressure monitoring in acute liver failure: a retrospective cohort study. Crit Care Med 2014; 42(5): 1157-67. [original work]
 
Karvellas CJ, Cavazos J, Battenhouse H, Durkalski V, Balko J, Sanders C, Lee WM; US Acute Liver Failure Study Group. Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure: a retrospective cohort study. Clin Gastroenterol Hepatol 2014; 12(11): 1942-9. [original work]
 
Dubin PH, Yuan H, Devine RK, Hynan LS, Jain MK, Lee WM; Acute Liver Failure Study Group. Micro-RNA-122 levels in acute liver failure and chronic hepatitis C. J Med Virol 2014; 86(9):1507-14. [original work]
 
Dai DF, Swanson PE, Krieger EV, Liou IW, Carithers RL, Yeh MM. Congestive hepatic fibrosis score: a novel histological assessment of clinical severity. Mod Pathol 2014;27(12):1552-8. [original work]
 
Long D, Fix OK, Deng X, Seielstad M, Lauring AS; Acute Liver Failure Study Group. Whole genome sequencing to identify host genetic risk factors for severe outcomes of hepatitis A virus infection. J Med Virol 2014; 86(10):1661-8. [original work]
 
Fontana RJ, Ellerbe C, Durkalski VE, Rangnekar A, Reddy RK, Stravitz T, McGuire B, Davern T, Reuben A, Liou I, Fix O, Ganger DR, Chung RT, Schilsky M, Han S, Hynan LS, Sanders C, Lee WM; the US Acute Liver Failure Study Group. Two-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study. Liver Int 2015; 35(2): 370-80. [original work]
 
Halldorson JB, Carithers RL, Bhattacharya R, Bakthavatsalam R, Liou IW, Dick AA, Reyes JD, Perkins JD. D-MELD risk capping improves post-transplant and overall mortality under Markov microsimulation. World J Transplant 2014;4(3):206-15. [original work]
 
Berry K, Taylor J, Liou IW, Ioannou GN. Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis. Clin Gastroenterol Hepatol 2015; 13(3):585-93. [original work]
 
Ingraham CR, Padia SA, Johnson GE, Easterling TR, Liou IW, Kanal KM, Valji K. Transjugular intrahepatic portosystemic shunt placement during pregnancy: a case series of five patients. Cardiovasc Intervent Radiol 2015; 39(5):1205-10. [original work]
 
Srungaram P, Rule JA, Yuan HJ, Reimold A, Dahl B, Sanders C, Lee WM; Acute Liver Failure Study Group. Plasma osteopontin in acute liver failure. Cytokine. 2015;72(2):270-276. [original work]
 
Basta G, Del Turco S, Navaarra T, Lee WM; Acute Liver Failure Study Group. Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure. Liver Transpl. 2015;:21(6):847-854. [original work]
 
Speiser JL, Lee WM, Karvellas CJ; US Acute Liver Failure Study Group. Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. PLos One 2015;10(4):e0122929. [original work]
 
Berry K, Lerrigo R, Liou IW, Ioannou GN. Association between transjugular intrahepatic portosystemic shunt and survival in patients with cirrhosis. Clin Gastroenterol Hepatol. 2016; 14(1): 118-23. [original work]
 
*James J, Liou IW. Comprehensive care of patients with chronic liver disease. Med Clin North Am 2015;99(5):913-33. [review]
 
Rule JA, Hynan LS, Attar N, Sanders C, Korzun WJ, Lee M; Acute Liver Failure Study Group. Procalcitonin identifies cell injury, not bacterial infection in acute liver failure. PLoS One. 2015 Sep 22; 10(9): e0138566. [original work]
 
Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvella CJ; US Acute Liver Failure Study Group. Detection of ophthalmic acid in serum from acetaminophen-induced acute liver failure patients is more frequent in non-survivors. PLoS One 2015;10(9):e0139299. [original work]
 
Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM; Acute Liver Failure Study Group. Association between plasma level of galectin-9 and survival of patients with drug-induced acute liver failure. Clin Gastroenterol Hepatol 2016;14(4):606-612. [original work]
 
 
Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN. Aging of liver transplant registrants and recipients: trends and impact on waitlist outcomes, post-transplant outcomes and transplant-related survival benefit. Gastroenterology 2016; 150(2):441-453. [original work]
 
Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Stravitz RT, McGuire BM, Fix OK: United States Acute Liver Failure Study Group. Acute liver injury and acute liver failure from mushroom poisoning in North America. Liver Int 2016; 36(7):1043-50. [original work]
 
Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Smith A, Brown R, Crippin J, Harrison ME, Koch D, Munoz S, Reddy KR, Rossaro L, Satyanaryana R, Hassanein T, Hanje AJ, Olson J, Subramanian R, Karvellas C, Hameed B, Sherker AH, Robuck P, Lee WM. Outcomes in adults with acute liver failure between 1998 and 2013: an observational cohort study. Ann Intern Med 2016; 164(11);724-32. [original work]
 
*Fix OK, Liou I, Karvellas CJ, Ganger DR, Forde KA, Subramanian RM, Boylan A, Hanje J, Stravitz RT, Lee WM; Acute Liver Failure Study Group. Development and pilot of a checklist for management of acute liver failure in the intensive care unit. PLoS One. 2016 May 13; 11(5):e0155500. [original work]
 
Karvellas CJ, Cardoso FS, Gottfried M, Reddy KR, Hanje AJ, Ganger D, Lee WM; US Acute Liver Failure Study Group. HBV-associated acute liver failure after immunosuppression and risk of death. Clin Gastroenterol Hepatol 2017;15(1):113-122. [original work]
 
Bowen SR, Chapman TR, Borgman J, Miyaoka RS, Kinahan PE, Liou IW, Sandison GA, Vesselle HJ, Nyflot MJ, Apisarnthanarax S. Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients. EJNMMI Res 2016; 6(1) :57. [original work]
 
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger, D, Reddy KR, Liou I, Fix O, James LP. An immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure. Clin Gastroenterol Hepatol. 2017;15(4):555-562. [original work]
 
Fontana RJ, Engle RE, Scaglione S, Araya V, Shaikh O, Tillman H, Attar N, Purcell RH, Lee WM; US Acute Liver Failure Study Group. The role of hepatitis E virus infection in adult Americans with acute liver failure. Hepatology 2016; 64(6):1870-1880. [original work]
 
Parekh J, Matei VM, Canas-Coto A, Friedman D, Lee WM; Acute Liver Failure Study Group. Budd-Chiari syndrome causing acute live failure: a multicenter case series. Liver Transpl. 2017;23(2):135-142. [original work]
 
*Liou IW, Nguyen MH. The cascade of care in chronic hepatitis B. Curr Hepatology Rep 2016;15:209-219. [review]
 
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP. An Immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure. Clin Gastroenterol Hepatol 2017; 15(4):555-562. [original work]
 
Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OH, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A. The natural history of severe acute liver injury. Am J Gastroenterol 2017;112(9):1389-1396. [original work]
 
Randesi M, Levran O, Corea da Rosa J, Handkins J, Rule J, Kreek MJ, Lee WM; Acute Liver Failure Study Group. Association of variants of arginine vasopressin and arginine vasopressin receptor 1A with severe acetaminophen liver injury. Cell Mol Gastroenterol Hepatol 2017; 3(3):500-505. [original work]
 
Bajema KL, Simonson PD, Greninger AL, Coruh B, Pottinger PS, Bhattacharya R, Liou IW, Jalikis FG, Fligner CL, Rakita RM. Acute liver failure due to Echovirus 9 associated with persistent B cell depletion from rituximab. Open Form Infectious Disease, ofx174, https://doi.org/10.1093/ofid/ofx174. Published 14 August 2017. [original work]
 
Chapman T, Bowen SR, Yeung R, Kwan SW, Park JO, Yu L, Harris WP, Johnson GE, Liou IW, Nyflot MJ, Apisarnthanarax S. Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: defining clinically relevant liver toxicity endpoints. Practical Radiation Oncology 2018; 8(3):157-166. [original work]
 
*Nguyen MH, Lim JK, Ozbay AB, Fraysse J, Liou I, Meyer N, Dusheiko G, Gordon SC. Advancing age and comorbidity in a United States insured population-based cohort of patients with chronic hepatitis B. Hepatology 2019; 69(3):959-973. [original work]
 
*Nguyen MH, Burak Ozbay A, Liou I, Meyer N, Gordon SC, Dusheiko G, Lim JK. Healthcare resource utilization and costs by disease severity in an insured national sample of US patients with chronic hepatitis B. J Hepatol. 2019; 70(1):24-32. [original work]
 
Bosch DE, Koro K, Richards E, Hoch BL, Jalikis F, Koch LK, Swanson PE, Truong CD, Liou I, Yu L, Bhattacharya R, Yeh MM. Validation of a congestive hepatic fibrosis scoring system. Am J Surg Pathol. 2019; 43(6):766-772. [original work]
 
Yu L, Liou IW, Biggins SW, Yeh M, Jalikis F, Chan LN, Burkhead J. Cooper deficiency in liver diseases: a case series and pathophysiological considerations. Hepatol Commun 2019; 3(8):1159-1165. [original work]
 
Puri P, Lee WM, Fontana RJ, Kim NK, Durkalski V, McGuire BM, Liou I, Pezzia C, Stravitz RT; Acute Liver Failure Study Group. Alcohol consumption is associated with the severity and outcome of acute liver injury/failure. Liver Int. 2020; 40(2): 360-367. [original work]
 
 
MacDonald AJ, Speiser JL, Ganger DR, Nilles KM, Orandi BJ, Larson AM, Lee WM, Karvellas CJ; US Acute Liver Failure Study Group. Clinical and neurologic outcomes in acetaminophen-induced acute liver failure: a 21-year multicenter cohort study. Clin Gastroenterol Hepatol. 2020 Sept 10. Online ahead of print. [original work]
 
Fontana RJ, Stravitz RT, Durkalski V, Hange J, Hameed B, Koch D, Ganger D, Olson J, Liou I, McGuire BM, Clasen K, Lee WM. Prognostic value of the 13C-methacetin breath test in adults with acute liver failure and non-acetaminophen acute liver injury. Hepatology 2021 March 3. Online ahead of print. [original work]
 
Tavabie OD, Karvellas CJ, Salehi S, Sepiser JL, Rose CF, Menon K, Prachalias A, Heneghan MA, Agarwal K, Lee WM, McPhail MJW, Aluvihare VR; United States Acute Liver Failure Study Group. J Hepatol 2021 Apri1 12. Online ahead of print [original work]