Teresa A. Brentnall
Professor
Medicine, Division of Gastroenterology
Joint Professor
Pathology

Faculty Information

Biography

Teri Brentnall, M.D., is a board certified physician at the Digestive Health Center at UW Medical Center and SCCA, co-director of the SCCA Pancreatic Cancer Surveillance Program, the UW's Charles and Mary Ann Walters Endowed Chair in Medicine and Gastroenterology and a UW professor of Pathology.

Dr. Brentnall is a clinical gastroenterologist who also is a cancer researcher. She specializes in caring for patients that have an elevated risk of intestinal cancer due to hereditary susceptibility. She enjoys caring for patients who are interested in a healthy lifestyle.

Dr. Brentnall earned her M.D. at the UW. She is working on earlier detection of pancreatic cancer and IBD-related colon cancer through the development of cancer biomarkers and molecular imaging.

Board Certifications:

  • Gastroenterology, 1997, American Board of Internal Medicine
Education & Training: 
Fellowship in Gastroenterology
University of Washington
Residency in Medicine
University of California, Los Angeles
Internship in Medicine
University of California, Los Angeles
Medical Education
University of Washington, School of Medicine
1987
Research & Clinical Interests
Clinical Interests: 
  • Gastroenterology
Publications
Publications: 
 
Burmer GC, Rabinovitch PS, Haggitt RC, Crispin DA, Brentnall TA, Kolli VR, Stevens A, and Rubin CE. Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele. Gastroenterology 1992; 103:1602-1610. [original work]
 
Rubin CE, Haggitt RC, Burmer GC, Brentnall TA, Stevens A, Levine DS, Dean PJ, Kimmey MB, Perera DR, and Rabinovitch PS. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 1992; 103:1611-1620. [original work]
 
Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, and Burmer GC. Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis. Gastroenterology 1994; 107:369-378. [original work] Presented at the Symposium on Tumor Suppressor gene American Gastroenterological Association
Meetings, 1993.
 
Brentnall TA. Microsatellite instability. Shifting concepts in tumorigenesis. Am J Pathol. 1995; 147: 561-3
 
Evans JP, Burke W, Chen R, Bennett RL, Schmidt RA, Dellinger P, Kimmey MB, Crispin DA, Brentnall TA, and Byrd DR. Familial Pancreatic Adenocarcinoma: Association with diabetes and exocrine insufficiency and early molecular diagnosis. J Med Genet 1995; 32:330-335. [original work]
 
Brentnall TA, Rubin CE, Crispin DA, Stevens AC, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Boland CR, Bilir N, and Rabinovitch PS. A germ-line substitution in the human MSH2 gene is associated with cancer and high grade dysplasia in ulcerative colitis. Gastroenterology 1995; 109:151-155. [original work]
 
Brentnall TA, Chen R, Lee JG, Kimmey MB, Bronner MP, Haggitt RC, Kowdley KV, Hecker LM, Byrd DR. Microsatellite instability and k-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res 1995; 55:4264-4267. [original work]
 
Kozarek R, Bedard C, Patterson D, Justus P, Sandford R, Greene M, Gelfand M, Bredfeldt J, Brentnall T, Putnam W, Silverman B, Brandabur J, Hinds J, Taubman G, Wagner K, Driscoll R, Mitchell W. Cyclosporin use in the precolectomy CUC patient: A community experience and its relationship to prospective and controlled clinical trials. Am J Gastroenterol 1995; 90:2093-2095. [original work]
 
Brentnall TA, Haggitt RC, Rabinovitch PS, Kimmey MB, Bronner MP, Levine DS, Kowdley KV, Stevens AC, Crispin DA, Emond M , Rubin CE. Risk and natural history of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1996; 110:331-338. PMID: 8566577 [original work]
 
Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 1996; 56:1237-1240. PMID: 8640805 [original work]
 
Wu D, Hockenbery DM, Brentnall TA, Baehr PH, Ponec RJ, Kuver RP, Tzung S-P, Todaro JL, McDonald GB. Persistent nausea and anorexia after marrow transplantation. A prospective study of 78 patients. Transplantation 1998; 66:1319-1324. PMID: 9846516 [original work]
 
Rabinovitch PS, Dziadon A, Brentnall TA, Emond MJ, Crispin DA, Haggitt RC, Bronner MB. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 1999; 59: 5148-5153. PMID: 10537290 [original work]
 
Brentnall TA. Cancer surveillance of patients from familial pancreatic cancer kindreds. Med Clin North Am. 2000; 84: 707-18. PMID: 10872427 [original work]
 
Agoff SN, Brentnall TA, Crispin DA, Taylor SL, Raaka S, Haggitt RC, Reed MW, Afonina IA, Rabinovitch PS, Stevens AC, Feng Z, Bronner MP. The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am J Pathol. 2000; 157: 737-745. PMID:10980113 [original work]
 
Tung BY, Emond MJ, Haggitt RC, Bronner MP, Kimmey MB, Kowdley KV, Brentnall TA. Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with primary sclerosing cholangitis. Ann Intern Med. 2001; 134: 89-95. PMID: 11177311 [original work]
 
Efthimou E, Crnogorac-Jurcevic T, Lemoine NR, Brentnall TA. Inherited predisposition to pancreatic cancer. Gut 2001; 48: 143-147. PMID: 11156628 [original work]
 
Issa J-P, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res. 2001, 61:3573-7. PMID: 11325821 [original work]
 
Meckler KA, Brentnall TA, Haggitt RC, Crispin D, Byrd DR, Kimmey MB, Bronner MP: Familial fibrocystic pancreatic atrophy with endocrine cell hyperplasia and pancreatic carcinoma. Am J Surg Pathol 2001, 25: 1047-1053. PMID: 11474289 [original work]
 
Rulyak SJ, Brentnall TA. Inherited Pancreatic Cancer: Surveillance and Treatment Strategies for Affected Families. Pancreatology. 2001; 1: 477-485. PMID:12120228 [original work]
 
Eberle MA, Pfützer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak L, Whitcomb DC, Brentnall TA. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genetics. 2002, 70:1044-1048. PMID: 11870593 [original work]
 
Kimmey MB, Brentnall TA, Bronner MP, Byrd, DR: Screening and surveillance for hereditary pancreatic cancer.
Gastrointestinal Endoscopy. 2002; 56: S82-6. PMID: 12297755 [original work]
 
O’Sullivan JN, Bronner MP, Teresa A. Brentnall TA. et al. Chromosomal instability in ulcerative colitis is related
to telomere shortening. Nat Genet. 2002; 32: 280-284. PMID: 12355086 [original work]
 
Yang J, Maronian N, Reyes V, Waugh P, Brentnall T, Hillel A. Laryngeal and other otolaryngologic manifestations
of Crohn's disease. J Voice. 2002; 16: 278-82. [original work]
 
Brentnall TA. Molecular underpinnings of cancer in ulcerative colitis. Curr Opin Gastroenterol. 2003; 19:64-8.
 
Rulyak SJ, Kimmey MB, Veenstra D, Brentnall TA. Cost-Effectiveness of Pancreatic Cancer Screening in Familial Pancreatic Cancer Kindreds. Gastrointest Endosc 2003; 57: 23-9. [original work]
 
Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Koprowicz KM, Bronner MP, Brentnall TA. DNA Fingerprinting Abnormalities Can Distinguish UC Patients with Dysplasia and Cancer From Those Who Are Dysplasia/Cancer Free. Am J Path. 2003; 162: 665-72. PMID:12547724 [original work]
 
Brentnall TA. Ursodiol: good drug makes good. Gastroenterology. 2003; 124:1139-40. PMID: 12671906
 
Rulyak SJ, Lowenfels AB, Maisonneuve P, Brentnall TA. Risk Factors for the Development of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds. Gastroenterology. 2003; 124: 1291-9. PMID:12730869 [original work]
 
Moskovitz AH, Linford NJ, Brentnall TA, Bronner MP, Storer BE, Potter JD, Bell RH Jr., Rabinovitch PS. Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma. Genes Chromosomes Cancer. 2003; 37: 201-6. PMID: 12696069 [original work]
 
Rulyak SJ, Brentnall TA, Lynch HT, Austin MA. Characterization of the neoplastic phenotype in the familial atypical multiple mole melanoma-pancreatic carcinoma syndrome. Cancer. 2003; 98 798-804. PMID:12910525 [original work]
 
Brentnall TA. UC for UC: ursodiol chemoprevention for ulcerative colitis. Inflamm Bowel Dis. 2003; 9: 338. PMID: 14570007 [editorial]
 
Rulyak SJ, Mandelson MT, Brentnall TA, Rutter CM, Wagner EH. Clinical and sociodemographic factors associated with colon surveillance among patients with a history of colorectal cancer. Gastrointest Endosc. 2004; 59:239-47. PMID: 14745398 [original work]
 
Charpentier KP, Brentnall TA, Bronner MP, Byrd D, Marsch C. A new indication for pancreas transplantation: high grade pancreatic dysplasia. Clin Transplant. 2004;18:105-7. PMID:15108779 [original work]
 
Bronner MP, Goldblum JR, Kimmey MB, Brentnall TA, Rubin CE. Low-grade dysplasia in ulcerative colitis: natural history data still unknown. Gastroenterology. 2004. 127:362-3. PMID:15236221 [original work]
 
Rulyak SJ, Brentnall TA. Inherited pancreatic cancer: improvements in our understanding of genetics and screening. Int J Biochem Cell Biol. 2004; 36: 1386-92. PMID: 15147717 [original work]
 
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G, Lemoine NR. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. Am J Pathol. 2005; 166: 81-92. PMID: 15632002 [original work]
 
Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W, Campbell F, Brentnall TA, Costello E, Neoptolemos J, Lemoine NR. Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology. 2005; 129:1454-63. PMID:16285947 [original work]
 
Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Bronner MP, Brentnall TA. The initiation of colon cancer in a chronic inflammatory setting. Carcinogenesis. 2005;26: 1513-9. PMID: 15860506 [original work]
 
Chen R, Pan S, Brentnall TA, Aebersold R. Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery. Molecular Cell Proteomics. 2005: 4.4: 523-33. PMID:15684406 [original work]
 
Brentnall TA. Management strategies for patients with hereditary pancreatic cancer. Current Treatment Options Oncol. 2005; 6:437-45. PMID: 16107246 [original work]
 
Chen R, Bronner MP, Crispin DA, Rabinovitch PS, Brentnall TA. Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions. Cancer Genetics and Cytogenetics 2005; 162: 99-106. PMID: 16213356 [original work]
 
Chen R, Yi E, Donohoe S, Pan S, Eng J, Cooke K, Keller A, Nesvizhskii A, Li X, Crispin D, Goodlett D, Bronner MP, Aebersold R, Brentnall TA. Pancreatic Cancer Proteome: The Proteins that Underlie Invasion, Metastasis, and Immunologic Escape. Gastroenterology 2005; 129:1187-97. PMID: 16230073. [original work]
 
Chen R, Pan S, Crispin D, Brentnall TA. Gene Expression and Proteomic Analysis of Pancreatic Cancer: a Recent Update. Cancer Genomics and Proteomics 2006; 3:1-10. [original work]
 
Chen R, Yi E, Donohoe D, Pan S, Bronner M, Goodlett D, Aebersold R, Brentnall T. 2006. Quantitative Proteomic Profiling of Pancreatic Cancer Juice. Proteomics 2006; 6:3871-9. PMID:16739137 [original work]
 
O'Sullivan J, Risques RA, Mandelson MT, Chen L, Brentnall TA, Bronner MP, Macmillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS. Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2006;15:573-7. PMID: 16537718 [original work]
 
Risques R, Rabinovich P, Brentnall T. Cancer surveillance in inflammatory bowel disease: new molecular approaches. Current Opinion in Gastroenterology 2006; 22: 382-90. PMID:16760754 [original work]
 
Kaz AM, Brentnall TA. Genetic testing for colon cancer. Nat Clin Pract Gastroenterol Hepatol. 2006; 3:670-9. PMID: 17130877 [review]
 
Hruban RH, Rustgi AK, Brentnall TA, Tempero MA, Wright CV, Tuveson DA. Pancreatic cancer in mice and man: the Penn Workshop 2004. Cancer Res. 2006; 66: 14-7. PMID:16397208 [original work]
 
Pogue-Geile KL, Chen R, Bronner MP, Crnogorac-Jurcevic T, Moyes KW, Dowen S, Otey CA, Crispin DA, George RD, Whitcomb DC, Brentnall TA. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. PLoS Med. 2006; 3:e516. PMID: 17194196 [original work]
 
Brand RE, Lerch MM, Rubinstein WS, Neoptolemos JP, Whitcomb DC, Hruban RH, Brentnall TA, Lynch HT, Canto MI; Participants of the Fourth International Symposium of Inherited Diseases of the Pancreas. Advances in counseling and surveillance of patients at risk for pancreatic cancer. Gut 2007; 56:1460-9. PMID: 17872573 [original
work]
 
Chen R, Brentnall TA, Pan S, Cooke K, Moyes KW, Lane Z, Crispin DA, Goodlett DR, Aebersold R, Bronner MP. Quatitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer. Mol Cell Proteomics. 2007; 6: 1331-42. PMID: 17496331 [original work]
 
Chen R, Pan S, Cooke K, Moyes KW, Bronner MP, Goodlett DR, Aebersold R, Brentnall TA. Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis. Pancreas. 2007; 34: 70- 9. PMID:17198186 [original work]
 
Chen R, Pan S, Aebersold R, Brentnall TA. Proteomics studies of pancreatic cancer. Proteomics Clin Appl. 2007; 1: 1582-1591. PMID: 18633454 [review]
 
Risques RA, Lai LA, Brentnall TA, Li L, Feng Z, Gallaher J, Mandelson MT, Potter JD, Bronner MP, Rabinovitch PS. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology 2008; 135: 410-8. PMID:18519043 [original work]
 
Bronner MP, O'Sullivan JN, Rabinovitch PS, Crispin DA, Chen L, Emond MJ, Rubin CE, Brentnall TA. Genomic biomarkers to improve ulcerative colitis neoplasia surveillance. Am J Pathol. 2008; 173: 1853-60. PMID:18988798 [original work]
 
Pan S, Aebersold R, Chen R, Rush J, Goodlett DR, McIntosh MW, Zhang J, Brentnall TA. Mass spectrometry based targeted protein quantification: methods and applications. Journal Proteome Res. 2009; 8: 787-97. PMID:19105742
 
Pan S, Chen R, Reimel BA, Crispin DA, Mirzaei H, Cooke K, Coleman JF, Lane Z, Bronner MP, Goodlett DR, McIntosh MW, Traverso W, Aebersold R, Brentnall TA. Quantitative proteomics investigation of pancreatic intraepithelial neoplasia. Electrophoresis 2009; 30:1132-44. PMID: 19373808 [original work]
 
Reimel BA, Pan S, May DH, Scott A, Shaffer SA Goodlett DR, McIntosh MW, Yerian LM, Bronner MP, Chen R, Brentnall TA. Proteomics on Fixed Tissue Specimens- A Review. Current Proteomics 2009; 6: 63-69. PMID: 19829741 [review]
 
 
Seibel EJ, Brentnall TA, Dominitz JA. New endoscopic and cytologic tools for cancer surveillance in the digestive tract. Gastrointest Endosc Clin N Am. 2009; 19: 299-307. PMID: 19423026 [review]
 
Brentnall TA, Pan S, Bronner MP, Crispin DA, Mirzaei H, Cooke K, Tamura Y, Nikolskaya T, Jebailey L, Goodlett DR, McIntosh M, Aebersold R, Rabinovitch PS, Chen R. Proteins That Underlie Neoplastic Progression of Ulcerative Colitis. Proteomics Clin Appl. 2009; 3:1326-1337. PMID: 20098637 [original work]
 
Salk JJ, Salipante SJ, Risques RA, Crispin DA, Li L, Bronner MP, Brentnall TA, Rabinovitch PS, Horwitz MS, Loeb LA. Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci USA. 2009; 106: 20871-6. PMID: 19926851. [original work]
 
Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall TA, et al. Selection criteria for genetic assessment of patients with familial melanoma. J Am Acad Dermatol. 2009; 61:677 e1- 14. PMID: 19751883 [original work]
 
Chen R, Crispin DA, Pan S, Hawley S, McIntosh MW, May D, Anton-Culver H, Ziogas A, Bronner MP, Brentnall TA. Pilot Study of Blood Biomarker Candidates for Detection of Pancreatic Cancer. Pancreas. 2010; 39:981-8. PMID: 20467349 [original work]
 
Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, et al. Isoform-specific up-regulation of palladin in human and murine pancreas tumors. PLoS One. 2010; 5:e10347. PMID: 20436683 [original work]
 
Fong PY, Fesinmeyer MD, White E, Farin FM, Srinouanprachanh S, Afsharinejad Z, Mandelson MT, Brentnall TA, Barnett MJ, Goodman GE, Austin MA. Association of Diabetes Susceptibility Gene Calpain-10 with Pancreatic Cancer Among Smokers. J Gastrointest Cancer. 2010; 41(3):203-8. PMID:20178008 [original work]
 
Chen R, Pan S, Xiaobo D, Nelson B, Sahota R, Chalk S, Kozarek R, McIntosh MW, Brentnall TA. Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Mol Cancer 2010; 9: 149. [Epub ahead of print] PMID: 20550709 [original work]
 
May D, Pan S, Crispin D, Lai K, Bronner MP, Hogan J, Hockenbery DM, McIntosh MW, Brentnall T, Chen R. Investigating neoplastic progression of ulcerative colitis with label-free comparative proteomics. J Proteome Res. J Proteome Res. 2011; 10:200-9. [Epub ahead of print]2010 Sep 10. PMID: 20828217 [original work]
 
Bronner MP, Skacel M, Crispin DA, Hoff PD, Emond MJ, Lai LA, Tubbs RR, O'Sullivan JN, Rabinovitch PS, Brentnall TA. Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors. Mod Pathol. 2010; 23:1624-33. PMID: 20802465 [original work]
 
Pan S, Chen R, Aebersold R, Brentnall TA. Mass spectrometry based glycoproteomics - from a proteomics perspective. Mol Cell Proteomics. 2011 10:R110.003251 [Epub ahead of print] PMID: 20736408 [review]
 
Carrigan PE, Bingham JL, Srinvasan S, Brentnall TA, Miller LJ. Characterization of alternative spliceoforms and the RNA splicing machinery in pancreatic cancer. Pancreas. 2011; 40: 281-8. PMID: 21178653 [original work]
 
Wang P, Bista RK, Khalbuss WE, Qiu W, Uttam S, Staton K, Zhang L, Brentnall TA, Brand RE, Liu Y. Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy. J Biomed Opt. 2010; 15: 066028. PMID:21198202 [original work]
 
May D, Pan S, Crispin DA, Lai K, Bronner MP, Hogan J, Hockenbery DM, McIntosh M, Brentnall TA, Chen R. Investigating neoplastic progression of ulcerative colitis with label-free comparative proteomics. J Proteome Res. 2011; 10:200-9. Epub 2010 Oct 20. PMID: 20828217 [original work]
 
Risques RA, Lai LA, Himmetoglu C, Ebaee A, Li L, Feng Z, Bronner MP, Al-Lahham B, Kowdley KV, Lindor KD, Rabinovitch PS, Brentnall TA. Ulcerative Colitis-Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation. Cancer Res 2011;71 1669-1679. PMID: 21363920 [original work]
 
Bista RK, Brentnall TA, Bronner MP, Langmead CJ, Brand RE, Liu Y. Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis-associated neoplasia. Inflamm Bowel Dis. 2011; 17:2427-35. PMID: 21351200 [original work]
 
Pan S, Chen R, Crispin DA, May D, Stevens T, McIntosh MW, Bronner MP, Ziogas A, Anton-Culver H, Brentnall TA. Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling. J Proteome Res. 2011; 10:2359-76. Epub 2011 Mar 28. PMID: 21443201 [original work]
 
Brentnall TA. Pancreatic cancer surveillance: learning as we go. Am J Gastroenterol. 2011; 106:955-6. [editorial]
 
Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR, Crnogorac-Jurcevic T. AGR2 is a Novel Surface Antigen that Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D. Cancer Res. 2011 Sep 26. [Epub ahead of print] PMID: 21948970 [original work]
 
Pan S, Chen R, Stevens T, Bronner MP, May D, Tamura Y, McIntosh MW, Brentnall TA. Proteomics portrait of archival lesions of chronic pancreatitis. PLoS One. 2011;6:e27574. Epub 2011 Nov 23. PMID: 22132114 [original work]
 
Brentnall TA, Lai LA, Coleman J, Bronner MP, Pan S, Chen R. Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to develop destructive behavior that promotes tumor invasion. PLoS One 2012: 7: e30219. PMID: 22291919 [original work]
 
Pan S, Chen R, Brand RE, Hawley S, Tamura Y, Gafken PR, Milless BP, Goodlett DR, Rush J, Brentnall TA. Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res. 2012; 11:1937-48. Epub 2012; 11:1937-48. PMID: 22316387 [original work]
 
Lai LA, Risques RA, Bronner MP, Rabinovitch PS, Crispin D, Chen R, Brentnall TA. Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer. Cancer Lett. 2012; 320(2):180-8. PMID: 22387989 [original work]
 
Zisman TL, Bronner MP, Rulyak S, Kowdley KV, Saunders M, Lee SD, Ko C, Kimmey MB, Stevens A, Maurer J, Brentnall TA. Prospective Study of the Progression of Low-Grade Dysplasia in Ulcerative Colitis Using Current Cancer Surveillance Guidelines. Inflamm Bowel Dis 2012. 18:2240-6. PMID: 22508402 [original work]
 
Brentnall TA. Arousal of cancer-associated stromal fibroblasts: expression of palladin activates fibroblasts to promote tumor invasion. Cell Adh Migr. 2012; 6: 488-94. Epub 2012 Oct 17 PMID: 23076142 [original work]
 
Brinton LT, Brentnall TA, Smith JA, Kelly KA. Metastatic biomarker discovery through proteomics. Cancer Genomics Proteomics. 2012; 9:345-55. PMID: 23
 
Pan S, Brentnall TA, Kelly K, Chen R. Tissue proteomics in pancreatic cancer study: Discovery, emerging technologies, and challenges. Proteomics. 2012; 13:710-21. PMID: 23125171 [review]
 
Pan S, Tamura Y, Chen R, May D, McIntosh MW, Brentnall TA. Large-scale quantitative glycoproteomics analysis of site-specific glycosylation occupancy. Mol Biosyst. 2012; 8:2850-6. Epub 2012 Aug 14. PMID: 22892896 [original work]
 
Chen R, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, Lane Z, Post J, Bronner MP, Willmann JK, Maitra A, Brentnall TA. Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma. Cancer Biol Ther. 2012;13: 899-907. Epub 2012 Aug 1. PMID: 22785208 [original work]
 
Templeton AW, Brentnall TA. Screening and surgical outcomes of familial pancreatic cancer. Surg Clin North Am. 2013; 93: 629-45.Epub 2013 Apr 13. PMID: 23632149 [review]
 
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M, Lemoine NR, Brentnall TA. Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One. 2013;8:e54830. Epub 2013 Jan 23. PMID: 23372777 [original work]
 
Wada K, Takaori K, Traverso LW, Hruban RH, Furukawa T, Brentnall TA, Hatori T, Sano K, Takada T, Majima Y, Shimosegawa T. Clinical importance of Familial Pancreatic Cancer Registry in Japan: a report from kick-off meeting at International Symposium on Pancreas Cancer 2012. J Hepatobiliary Pancreat Sci. 2013 Apr 19. [Epub ahead of print] PMID: 23604538 [original work]
 
Foygel K, Wang H, Machtaler S, Lutz AM, Chen R, Pysz M, Lowe AW, Tian L, Carrigan T, Brentnall TA, Willmann JK. Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1. Gastroenterology. 2013; 145:885-894.e3.[Epub ahead of print] PMID: 23791701 [original work]
 
Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS, Risques RA. Mitochondria and Tumor Progression in Ulcerative Colitis. J Natl Cancer Inst. 2013; 105: 1239-48. PMID: 23852949. [original work]
 
Austin MA, Kuo E, Van Den Eeden SK, Mandelson MT, Brentnall TA, Kamineni A, Potter JD. Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: The PACIFIC Study. Cancer Epidemiol Biomarkers Prev. 2013 Aug 21[Epub ahead of print] PMID: 23966578 [original work]
 
Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Proc Natl Acad Sci U S A. 2013; 110:19414-9. Epub 2013 Nov 11. PMID: 24218614 [original work]
 
Pan S, Chen R, Tamura Y, Crispin DA, Lai LA, May DH, McIntosh MW, Goodlett DR, Brentnall TA. Quantitative Glycoproteomics Analysis Reveals Changes in N-Glycosylation Level Associated with Pancreatic Ductal Adenocarcinoma. J Proteome Res. 2014 Jan 28. [Epub ahead of print] PMID: 24471499 [original work]
 
Chen R, Pan S, Lai K, Lai LA, Crispin DA, Bronner MP, Brentnall TA. Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer. World J Gastroenterol. 2014; 20:17037-48. PMID: 25493016 [original work]
 
Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA. Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. Lab Invest. 2015; 95: 43-55. Epub 2014 Oct 27. PMID: 25347153 [original work]
 
Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK. Vascular Endothelial Growth Factor Receptor Type 2-targeted Contrast-enhanced US of Pancreatic Cancer Neovasculature in a Genetically Engineered Mouse Model: Potential for Earlier Detection. Radiology. 2015; 274: 790-9. Epub 2014 Oct 14. PMID: 25322341 [original work]
 
Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA. Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel Dis. 2013;19:2593-602. PMID: 24097228 [original work]
 
Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of sporadic pancreatic cancer: summative review. Pancreas. 2015; 44: 693-712. PMID: 25931254 [review]
 
Pan S, Brentnall TA, Chen R. Proteomics analysis of bodily fluids in pancreatic cancer. Proteomics. 2015; 15: 2705-15. Epub 2015 Apr 27. PMID: 25780901 [review]
 
Laeseke PF, Chen R, Jeffrey RB, Brentnall TA, Willmann JK. Combining in Vitro Diagnostics with in Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions. Radiology. 2015; 277:644-61. PMID: 26599925 [review]
 
Brentnall TA. Progress in the Earlier Detection of Pancreatic Cancer. J Clin Oncol. 2016; 34: 1973-4. Epub 2016 Apr 25. PMID: 27114591 [editorial]
 
Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA. Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report. Pancreas. 2016; 45:1080-91. PMID: 27518363
 
Pan S, Brentnall TA, Chen R. Glycoproteins and glycoproteomics in pancreatic cancer. World J Gastroenterol. 2016; 22: 9288-9299. Review. PMID: 27895417
 
Dimastromatteo J, Brentnall T, Kelly KA. Imaging in pancreatic disease. Nat Rev Gastroenterol Hepatol. 2016 Nov 9. [Epub ahead of print] Review. PMID: 27826137.
 
Chen R, Lai LA, Brentnall TA, Pan S. Biomarkers for colitis-associated colorectal cancer. World J Gastroenterol. 2016; 22: 7882-91. Review. PMID: 27672285
 
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Gut. 2017; 66:852-862. Epub 2016 Jan 14. PMID: 28389570
 
Nigjeh EN, Chen R, Allen-Tamura Y, Brand RE, Brentnall TA, Pan S. Spectral library-based glycopeptide analysis-detection of circulating galectin-3 binding protein in pancreatic cancer. Proteomics Clin Appl. 2017; 11. Epub 2017 Jul 10. PMID: 28627758
 
Nigjeh EN, Chen R, Brand RE, Petersen GM, Chari ST, von Haller PD, Eng JK, Feng Z, Yan Q, Brentnall TA, Pan S. Quantitative Proteomics Based on Optimized Data-Independent Acquisition in Plasma Analysis. J Proteome Res. 2017 Jan 3. [Epub ahead of print] PMID: 27995795
 
Chen R, Lai LA, Sullivan Y, Wong M, Wang L, Riddell J, Jung L, Pillarisetty VG, Brentnall TA, Pan S. Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer. Sci Rep. 2017; 7: 7950. PMID: 28801576
 
Baker KT, Salk JJ, Brentnall TA, Risques RA. Precancer in Ulcerative Colitis: The Role of the Field Effect and its Clinical Implications. Carcinogenesis. 2017 Oct 26. [Epub ahead of print] PMID: 29087436
 
Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, et al.. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Rep. 2018; 23:2819-2831.PMID: 29847809
 
Baker KT, Nachmanson D, Kumar S, Emond MJ, Ussakli C, Brentnall TA, Kennedy SR, Risques RA. Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer. Mol Cancer Res. 2019; 17:488-498. Epub 2018 Nov 16. PMID: 30446624
 
Peng H, Chen R, Brentnall TA, Eng JK, Picozzi VJ, Pan S. Predictive proteomic signatures for response of pancreatic cancer patients receiving chemotherapy. Clin Proteomics. 2019;16:31. PMID: 31346328
 
 
Pan S, Brentnall TA, Cheng R. Proteome alterations in pancreatic ductal adenocarcinoma. Cancer Letters 2020, 469: 429-43. PMID: 31734355