William M. Grady
Professor
Rodger C. Haggitt Professor of Medicine
Division of Gastroenterology
Member, Fred Hutchinson Cancer Research Center

Faculty Information

Biography

William Grady, M.D., is a board certified physician at the Digestive Health Center at UW Medical Center, the UW Rodger C. Haggitt Professor of Medicine, director of Translational Research in Gastroenterology and a UW professor of Gastroenterology and Medicine. He is also a full member of the Fred Hutchinson Cancer Research Center and the medical director of the GI Cancer Prevention Program Clinic at SCCA.

Dr. Grady specializes in gastroenterology and internal medicine. He strives to create active partnerships with his patients to achieve the best possible outcomes.

Dr. Grady earned his M.D. at the University of Michigan. He is board certified in both Gastroenterology and Internal Medicine. His clinical interests include the diagnosis and treatment of hereditary cancer syndromes, as well as the development and use of molecular markers for the prevention and treatment of colon, esophageal and stomach cancer.

Board Certifications:

  • Gastroenterology, 1997, American Board of Internal Medicine
  • Internal Medicine, 1993, American Board of Internal Medicine
Education & Training: 
Fellowship in Gastroenterology
Case Western Reserve University
Fellowship in Gastroenterology
University of Michigan Medical Center
Residency in General Internal Medicine
University of Washington
Internship in General Internal Medicine
University of Washington
Medical Education
University of Michigan School of Medicine
Research & Clinical Interests
Clinical Interests: 
  • Gastroenterology
Publications
Publications: 
Li Y, Bai L, Yu H, Cai D, Wang X, Huang B, Peng S, Huang M, Cao G, Kaz AM, Grady WM, Wang J, Luo Y. Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer. Cancer Res. 2020 Dec 1;80(23):5203-5215. Epub 2020 Oct 13. PMID: 33051252
 
Geijsen AJMR, Ulvik A, Gigic B, Kok DE, van Duijnhoven FJB, Holowatyj AN, Brezina S, van Roekel EH, Baierl A, Bergmann MM, Böhm J, Bours MJL, Brenner H, Breukink SO, Bronner MP, Chang-Claude J, de Wilt JHW, Grady WM, Grünberger T, Gumpenberger T, Herpel E, Hoffmeister M, Huang LC, Jedrzkiewicz JD, Keulen ETP, Kiblawi R, Kölsch T, Koole JL, Kosma K, Kouwenhoven EA, Kruyt FM, Kvalheim G, Li CI, Lin T, Ose J, Pickron TB, Scaife CL, Schirmacher P, Schneider MA, Schrotz-King P, Singer MC, Swanson ER, van Duijvendijk P, van Halteren HK, van Zutphen M, Vickers K, Vogelaar FJ, Wesselink E, Habermann N, Ulrich AB, Ueland PM, Weijenberg MP, Gsur A, Ulrich CM, Kampman E. Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival. JNCI Cancer Spectr. 2020 Jul 7;4(5) 2020 PMID: 33134831
 
Gigic B, Nattenmüller J, Schneider M, Kulu Y, Syrjala KL, Böhm J, Schrotz-King P, Brenner H, Colditz GA, Figueiredo JC, Grady WM, Li CI, Shibata D, Siegel EM, Toriola AT, Kauczor HU, Ulrich A, Ulrich CM. The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study. Nutrients. 2020 Apr 28;12(5):1247. doi: 10.3390/nu12051247. PMID: 32353960
 
Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, Hüneburg R, Burn J, Castells A, Gallinger S, Lim R, Stoffel EM, Gupta S, Henderson A, Kallenberg FG, Kanth P, Roos VH, Ginsberg GG, Sinicrope FA, Strassburg CP, Van Cutsem E, Church J, Lalloo F, Willingham FF, Wise PE, Grady WM, Ford M, Weiss JM, Gryfe R, Rustgi AK, Syngal S, Cohen A.Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis. N Engl J Med. 2020 Sep 10;383(11):1028-1039. PMID: 32905675
 
Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States. Clin Gastroenterol Hepatol. 2020 Jul 4:S1542-3565(20)30917-4. PMID: 32634626
 
Han CJ, Gigic B, Schneider M, Kulu Y, Peoples AR, Ose J, Kölsch T, Jacobsen PB, Colditz GA, Figueiredo JC, Grady WM, Li CI, Shibata D, Siegel EM, Toriola AT, Ulrich AB, Syrjala KL, Ulrich CM. Risk factors for cancer-related distress in colorectal cancer survivors: one year post surgery. J Cancer Surviv. 2020 Mar 12. doi: 10.1007/s11764-019-00845-y.
 
Meeker SM, Seamons A, Treuting PM, Paik J, Brabb T, Hsu CC, Grady WM, Maggio-Price L. Effect of Chronic Vitamin D Deficiency on the Development and Severity of DSS-Induced Colon Cancer in Smad3-/- Mice. Comp Med. 2020 Apr 1;70(2):120-130. doi: 10.30802/AALAS-CM-19-000021. Epub 2020 Feb 3.PMID: 32014085
 
Wang T, Maden SK, Luebeck GE, Li CI, Newcomb PA, Ulrich CM, Joo J-H E, Buchanan DD, Milne RL, Southey MC, Carter KT, Willbanks AR, Luo Y, Yu M, Grady WM. Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk. Clinical Epigenetics 2020, in press
 
Gupta S, Provenzale D, Llor X, Halverson AL, Grady W, Chung DC, Haraldsdottir S, Markowitz AJ, Slavin TP Jr, Hampel H; CGC, Ness RM, Weiss JM, Ahnen DJ, Chen LM, Cooper G, Early DS, Giardiello FM, Hall MJ, Hamilton SR, Kanth P, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Mikkelson J; CGC, Peter S, Regenbogen SE, Dwyer MA; CGC, Ogba N.NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. J Natl Compr Canc Netw. 2019 Sep 1;17(9):1032-1041.PMID:31487681
 
Guo Y, Ayers JL, Carter KT, Wang T, Maden SK, Edmonds E, Newcomb PP, Li C, Ulrich C, Grady WM. Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. Aging Cell 1-12. 2019
 
Niu X, Amendola LM, Hart R, Bennette CS, Heagerty P, Horike-Pyne M, Trinidad SB, Rosenthal EA, Comstock B, Nefcy C, Hisama FM, Bennett RL, Grady WM, Gallego CJ, Tarczy-Hornoch P, Fullerton SM, Burke W, Regier DA, Dorschner MO, Shirts BH, Robertson PD, Nickerson DA, Patrick DL, Jarvik GP, Veenstra DL.Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study. Contemp Clin Trials. 2019 Sep;84:Epub 2019 Aug 7.PMID31400517
 
Pickhardt PJ, Pooler BD, Matkowskyj KA, Kim DH, Grady WM, Halberg RB. Volumetric growth rates of sessile serrated adenomas/polyps observed in situ at longitudinal CT colonography. Eur Radiol. 2019 Feb 11. doi: 10.1007/s00330-019-5999-0. [Epub ahead of print] PMID: 30741343
 
Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Sci Rep. 2018 Nov 23;8(1):17292. PMID:30470817
 
Luebeck GE, Hazelton WD, Curtius K, Maden SK, Yu M, Carter KT, Burke W, Lampe PD, Li CI, Ulrich CM, Newcomb PA, Westerhoff M, Kaz AM, Luo Y, Inadomi JM, Grady WM. Implications of epigenetic drift in colorectal neoplasia. Cancer Res. 2018 Oct 5. pii: canres.1682.2018. doi: 10.1158/0008-5472.CAN-18-1682. [Epub ahead of print] PMID:30291105
 
Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, Conti DV, Qu C, Jeon J, Edlund CK, Greenside P, Wainberg M, Schumacher FR, Smith JD, Levine DM, Nelson SC, Sinnott-Armstrong NA, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Bamia C, Banbury BL, Baron JA, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Chirlaque MD, Cho SH, Connolly CM, Cross AJ, Cuk K, Curtis KR, de la Chapelle A, Doheny KF, Duggan D, Easton DF, Elias SG, Elliott F, English DR, Feskens EJM, Figueiredo JC, Fischer R, FitzGerald LM, Forman D, Gala M, Gallinger S, Gauderman WJ, Giles GG, Gillanders E, Gong J, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hampel H, Harlid S, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Hunter DJ, Ibañez-Sanz G, Idos GE, Ingersoll R, Jackson RD, Jacobs EJ, Jenkins MA, Joshi AD, Joshu CE, Keku TO, Key TJ, Kim HR, Kobayashi E, Kolonel LN, Kooperberg C, Kühn T, Küry S, Kweon SS, Larsson SC, Laurie CA, Le Marchand L, Leal SM, Lee SC, Lejbkowicz F, Lemire M, Li CI, Li L, Lieb W, Lin Y, Lindblom A, Lindor NM, Ling H, Louie TL, Männistö S, Markowitz SD, Martín V, Masala G, McNeil CE, Melas M, Milne RL, Moreno L, Murphy N, Myte R, Naccarati A, Newcomb PA, Offit K, Ogino S, Onland-Moret NC, Pardini B, Parfrey PS, Pearlman R, Perduca V, Pharoah PDP, Pinchev M, Platz EA, Prentice RL, Pugh E, Raskin L, Rennert G, Rennert HS, Riboli E, Rodríguez-Barranco M, Romm J, Sakoda LC, Schafmayer C, Schoen RE, Seminara D, Shah M, Shelford T, Shin MH, Shulman K, Sieri S, Slattery ML, Southey MC, Stadler ZK, Stegmaier C, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Thomas SS, Toland AE, Trichopoulou A, Ulrich CM, Van Den Berg DJ, van Duijnhoven FJB, Van Guelpen B, van Kranen H, Vijai J, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Win AK, Wolf CR, Wolk A, Woods MO, Wu AH, Zaidi SH, Zanke BW, Zhang Q, Zheng W, Scacheri PC, Potter JD, Bassik MC, Kundaje A, Casey G, Moreno V, Abecasis GR, Nickerson DA, Gruber SB, Hsu L, Peters U. Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2018 Dec 3. doi: 10.1038/s41588-018-0286-6. [Epub ahead of print] PMID:30510241
 
Ulrich CM, Gigic B, Böhm J, Ose J, Viskochil R, Schneider M, Colditz GA, Figueiredo JC, Grady WM, Li CI, Shibata D, Siegel EM, Toriola AT, Ulrich A. The ColoCare Study - A paradigm of transdisciplinary science in colorectal cancer outcomes. Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):591-601. doi: 10.1158/1055-9965.EPI-18-0773. Epub 2018 Dec 6. PMID:30523039
 
Wang X, Dai JY, Albanes D, Arndt V, Berndt SI, Bézieau S, Brenner H, Buchanan DD, Butterbach K, Caan B, Casey G, Campbell PT, Chan AT, Chen Z, Chang-Claude J, Cotterchio M, Easton DF, Giles GG, Giovannucci E, Grady WM, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi AD, Lampe JW, Larsson SC, Lejbkowicz F, Li L, Lindblom A, Le Marchand L, Martin V, Milne RL, Moreno V, Newcomb PA, Offitt K, Ogino S, Pharoah PDP, Pinchev M, Potter JD, Rennert HS, Rennert G, Saliba W, Schafmayer C, Schoen RE, Schrotz-King P, Slattery ML, Song M, Stegmaier C, Weinstein SJ, Wolk A, Woods MO, Wu AH, Gruber SB, Peters U, White E. Int J Epidemiol. 2018 Nov 21. doi: 10.1093/ije/dyy244. [Epub ahead of print] PMID:30476131 Mendelian randomization analysis of C-reactive protein on colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2018 Dec 6. pii: cebp.0773.2018. doi: 10.1158/1055-9965.EPI-18-0773. [Epub ahead of print] PMID:30523039
 
Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, Nassir R, Vickers KT, Li C, Grady WM, Peters U, Jarvik GP; NHLBI GO Exome Sequencing Project. Rare loss of function variants in candidate genes and risk of colorectal cancer. Hum Genet. 2018 Sep 28. doi: 10.1007/s00439-018-1938-4. [Epub ahead of print]
 
Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM.
Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Gut. 2018 Jun 8. pii: gutjnl-2017-314544. doi: 10.1136/gutjnl-2017-314544.PMID:29884612
 
Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell. 2018 Jun 18;45(6):738-752.e6. PMID:29920278
 
Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Kono S, Kooperberg C, Krogh V, Kuehn T, Küry S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, Levine D, Li CI, Li L, Lieb W, Lin Y, Lindor NM, Liu YR, Loupakis F, Lu Y, Luh F, Ma J, Mancao C, Manion FJ, Markowitz SD, Martin V, Matsuda K, Matsuo K, McDonnell KJ, McNeil CE, Milne R, Molina AJ, Mukherjee B, Murphy N, Newcomb PA, Offit K, Omichessan H, Palli D, Cotoré JPP, Pérez-Mayoral J, Pharoah PD, Potter JD, Qu C, Raskin L, Rennert G, Rennert HS, Riggs BM, Schafmayer C, Schoen RE, Sellers TA, Seminara D, Severi G, Shi W, Shibata D, Shu XO, Siegel EM, Slattery ML, Southey M, Stadler ZK, Stern MC, Stintzing S, Taverna D, Thibodeau SN, Thomas DC, Trichopoulou A, Tsugane S, Ulrich CM, van Duijnhoven FJB, van Guelpan B, Vijai J, Virtamo J, Weinstein SJ, White E, Win AK, Wolk A, Woods M, Wu AH, Wu K, Xiang YB, Yen Y, Zanke BW, Zeng YX, Zhang B, Zubair N, Kweon SS, Figueiredo JC, Zheng W, Marchand LL, Lindblom A, Moreno V, Peters U, Casey G, Hsu L, Conti DV, Gruber SB. Novel common genetic susceptibility loci for colorectal cancer. J Natl Cancer Inst. 2018 Jun 16. [Epub ahead of print] PMID:29917119
 
Neumeyer S, Banbury BL, Arndt V, Berndt SI, Bezieau S, Bien SA, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Casey G, Chan AT, Chanock SJ, Dai JY, Gallinger S, Giovannucci EL, Giles GG, Grady WM, Hampe J, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi A, Larsson SC, Le Marchand L, Lindblom A, Moreno V, Lemire M, Li L, Lin Y, Offit K, Newcomb PA, Pharaoh PD, Potter JD, Qi L, Rennert G, Schafmayer C, Schoen RE, Slattery ML, Song M, Ulrich CM, Win AK, White E, Wolk A, Woods MO, Wu AH, Gruber SB, Brenner H, Peters U, Chang-Claude J. Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer. 2018 May 24. doi: 10.1038/s41416-018-0108-8. PMID:29795306
 
Chan MQ, Blum AE, Chandar AK, Emmons AMLK, Shindo Y, Brock W, Falk GW, Canto MI, Wang JS, Iyer PG, Shaheen NJ, Grady WM, Abrams JA, Thota PN, Guda KK, Chak A. Association of sporadic and familial Barrett's esophagus with breast cancer. Dis Esophagus. 2018 Apr 1;31(4). doi: 10.1093/dote/doy007. PMID:29528378
 
Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski P, Leiserson MDM, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U. Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov. 2018 Jun;8(6):730-749. doi: 10.1158/2159-8290.CD-17-1327. Epub 2018 Mar 6.
 
Grady W, Silvertein B, Surawicz C. Small bowel/Colon 3. University of Washington Gut Course syllabus April 1, 2018. 405-434.
 
Luebeck EG, Curtius K, Hazelton WD, Maden S, Yu M, Thota PN, Patil DT, Chak A, Willis JE, Grady WM. Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. Clin Epigenetics. 2017 Oct 16;9:113. doi: 10.1186/s13148-017-0409-4. eCollection 2017. PMID: 29046735
 
Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, Maden S, Vanzati A, Zavattari P, Matullo G, Truini M, Grady WM, Racca P, Michels KB, Siena S, Esteller M, Bardelli A, Sartore-Bianchi A, Di Nicolantonio F. Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Gut. 2017 Oct 5. pii: gutjnl-2016-313372. doi: 10.1136/gutjnl-2016-313372. [Epub ahead of print PMID: 28982739
 
Yuan X, Baker K, Redman MW, Wang L, Adams SV, Yu M, Dickinson B, Makar K, Ulrich CM, Böhm J, Wurshur M, Westerhoff M, Medwell S, Moonka R, Sinanan M, Fichera A, Vickers K, Grady WM. Dynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer. British J Cancer. 2017 Oct 10;117(8):1202-1210. doi: 10.1038/bjc.2017.266. Epub 2017 Aug 15. PMID:28809863
 
Cohen SA, Yu M, Baker K, Redman M, Wu C, Heinzerling TJ, Wirtz RM, Charalambous E, Pentheroudakis G, Kotoula V, Kalogeras KT, Fountzilas G, Grady WM. The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. Clin Epigenetics. 2017 May 2;9:46. doi: 10.1186/s13148-017-0347-1. eCollection 2017.
 
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.
 
Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-21β superfamily as a regulator of XIST expression. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1619-1624. doi: 10.1073/pnas. 1621356114. PMID:28143937
 
SM Morris, J Davison, KT Carter, RaM O’Leary, P Trobridge, SE Knoblaugh, LL Myeroff, SD Markowitz, BT Brett, TE Scheetz, AJ Dupuy, TK Starr, and WM Grady. Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms. International Journal of Cancer 2017 Feb 15;140(4):853-863. doi: 10.1002/ijc.30491. Epub 2016 Nov 7.PMID:27790711
 
Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M. MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5481-90. doi: 10.1073/pnas.1610994113. Epub 2016 Aug 26. PMID:27566402
 
Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Clin Epigenetics. 2016 Oct 27;8:111.PMID:27795744
 
Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay RM. Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12192-12197. PMID:27791005.
 
Provenzale D, Gupta S, Ahnen DJ, Bray T, Cannon JA, Cooper G, David DS, Early DS, Erwin D, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Regenbogen SE, Samadder NJ, Shike M, Steinbach G, Weinberg D, Dwyer M, Darlow S. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 Aug;14(8):1010-30.
 
Sun X, Elston R, Falk GW, Grady WM, Faulx A, Mittal SK, Canto MI, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Willis JE, Guda K, Markowitz S, Barnholtz-Sloan JS, Chandar A, Brock W, Chak A. Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas. Mol Genet Genomic Med. 2016 Mar 14;4(4):407-19.
 
Green RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium. Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. Am J Hum Genet. 2016 Jul 7;99(1):246. doi: 10.1016/j.ajhg.2016.06.002.
 
Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM, Wang J.. Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation. Tumour Biol. 2016 Jun 23. [Epub ahead of print] PMID:27333992
 
Cohen SA, Turner EH, Beightol MB, Jacobson A, Gooley TA, Salipante SJ, Haraldsdottir S, Smith C, Scroggins S, Tait JF, Grady WM, Lin EH, Cohn DE, Goodfellow PJ, Arnold MW, de la Chapelle A, Pearlman R, Hampel H, Pritchard CC. Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors with 2 or More Somatic Mutations in Mismatch Repair Genes..Gastroenterology. 2016 Jun 11. [Epub ahead of print] PMID:27302833
 
Curtius K, Wong CJ, Hazelton WD, Kaz AM, Chak A, Willis JE, Grady WM, Luebeck EG A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol. 2016 May 11;12(5):e1004919. doi: 10.1371/journal.pcbi.1004919. eCollection 2016 May.PMID:27168458
 
Green RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium.Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. Am J Hum Genet. 2016 Jun 2;98(6):1051-66. doi: 10.1016/j.ajhg.2016.04.011. Epub 2016 May 12. PMID:27181682
 
Bosch LJ, Luo Y, Valinluck Lao V, Snaebjornsson P, Trooskens G, Vlassenbroeck I, Mongera S, Tang W, Welcsh P, Herman JG, Koopman M, Nagtegaal I, Punt CJ, Van Criekinge W, Meijer GA, Monnat RJ, Carvalho B, Grady WM. WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy. Clin Cancer Res. 2016 Apr 27. pii: clincanres.2703.2015. PMID: 27121793
 
Sun X, Elston RC, Barnholtz-Sloan JS, Falk GW, Grady WM, Faulx A, Mittal SK, Canto M, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Tian YD, Willis JE, Guda K, Markowitz SD, Chandar A, Warfe JM, Brock W, Chak A. Predicting Barrett's esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm. Cancer Epidemiol Biomarkers Prev. 2016 Feb 29. pii: cebp.0832.2015. [Epub ahead of print] PMID: 26929243
 
Cohen SA, Wu C, Yu M, Gourgioti G, Wirtz R, Raptou G, Gkakou C, Kotoula V, Pentheroudakis G, Papaxoinis G, Karavasilis V, Pectasides D, Kalogeras KT, Fountzilas G, Grady WM. Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. Clin Colorectal Cancer. 2015 Nov 11.
 
Cohen SA, Laurino M, Bowen DJ, Upton MP, Pritchard C, Hisama F, Jarvik G, Fichera A, Sjoding B, Bennett RL, Naylor L, Jacobson A, Burke W, Grady WM. Initiation of universal tumor screening for Lynch syndrome in colorectal cancer patients as a model for the implementation of genetic information into clinical oncology practice. Cancer. 2015 Oct 19. Epub PMID:26480326
 
Yu M, Carter KT, Makar KW, Vickers K, Ulrich CM, Schoen RE, Brenner D, Markowitz SD, Grady WM. Methylight digital droplet PCR for detection and absolute quantification of infrequent methylated alleles. Epigenetics. 2015 Sep 2;10(9):803-9..PMID:26186366
 
Yu M, O’Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong C-J, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM. Methylated B3GAT2 and ZNF793 are potential detection biomarkers for Barrett’s esophagus. Cancer, Epidemiology, Biomarkers and Prevention 2015, epub.
 
Gallego CJ, Shirts BH, Bennette CS, Guzauskas G, Amendola LM, Horike-Pyne M, Hisama FM, Pritchard CC, Grady WM, Burke W, Jarvik GP, Veenstra DL. Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis Syndromes: A Cost-Effectiveness Analysis. J Clinical Oncology 2015 Jun 20;33(18):2084-91. doi: 10.1200/JCO.2014.59.3665. Epub 2015 May 4. PMID:25940718
 
Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, Jarvik ER, Itsara A, Turner EH, Herman DS, Schleit J, Burt A, Jamal SM, Abrudan JL, Johnson AD, Conlin LK, Dulik MC, Santani A, Metterville DR, Kelly M, Foreman AK, Lee K, Taylor KD, Guo X, Crooks K, Kiedrowski LA, Raffel LJ, Gordon O, Machini K, Desnick RJ, Biesecker LG, Lubitz SA, Mulchandani S, Cooper GM, Joffe S, Richards CS, Yang Y, Rotter JI, Rich SS, O'Donnell CJ, Berg JS, Spinner NB, Evans JP, Fullerton SM, Leppig KA, Bennett RL, Bird T, Sybert VP, Grady WM, Tabor HK, Kim JH, Bamshad MJ, Wilfond B, Motulsky AG, Scott CR, Pritchard CC, Walsh TD, Burke W, Raskind WH, Byers P, Hisama FM, Rehm H, Nickerson DA, Jarvik GP. Actionable exomic incidental findings in 6503 participants: challenges of variant classification. Genome Research 2015. epub
 
Pritchard CC, Morrissey C, Kumar A, Zhang X, Smith C, Coleman I, Salipante SJ, Milbank J, Yu M, Grady WM, Tait JF, Corey E, Vessella RL, Walsh T, Shendure J, Nelson PS. Complex MSH2 and MSH6 mutations in hypermutated microsatellite Nat Commun. 2014 Sep 25;5:4988. doi: 10.1038/ncomms5988.
 
Morris SM, Carter KT, Baek JY, Koszarek A, Yeh MM, Knoblaugh SE, Grady WM. TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene 2014 Aug 18;0. doi: 10.1038/onc.2014.258. [Epub ahead of print]
 
Pavelitz T, Renfro L, Foster NR, Caracol A, Welsch P, Lao VV, Grady WB, Niedzwiecki D, Saltz LB, Bertagnolli MM, Goldberg RM, Rabinovitch PS, Emond M, Monnat RJ Jr, Maizels N. MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial. PLoSOne 2014 Oct 13;9(10):e108483. doi: 10.1371/journal.pone.0108483. eCollection 2014. PMID: 25310185 [PubMed - in process]
 
Meeker S, Seamons A, Paik J, Treuting PM, Brabb T, Grady WM, Maggio-Price L. Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Cancer Research 2014 Aug 15;74(16):4398-408
 
Gallego CJ, Bennette CS, Heagerty P, Comstock B, Horike-Pyne M, Hisama F, Amendola LM, Bennett RL, Dorschner MO, Tarczy-Hornoch P, Grady WM, Fullerton SM, Trinidad SB, Regier DA, Nickerson DA, Burke W, Patrick DL, Jarvik GP, Veenstra DL. Comparative effectiveness of next generation genomic sequencing for disease diagnosis: Design of a randomized controlled trial in patients with colorectal cancer/polyposis syndromes. Contemporary Clinical Trials 2014. 39(1); 1-8.
 
Shiovitz S, Copeland WK, Passarelli MN, Burnett-Hartman AN, Grady WM, Potter JD, Gallinger S, Buchanan DD, Rosty C, Win AK, Jenkins M, Thibodeau SN, Haile R, Baron JA, Marchand LL, Newcomb PA, Lindor NM. Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer. Br J Cancer. 2014 Jul 29;111(3):598-602
 
Khatavevich D, Page T, Gresswell C, Hayamizu Y, Grady W, Sarikaya M. Selective detection of target proteins by peptide-enabled graphene biosensor. Small. 2014 Apr 24;10(8):1505-13, 1504. doi: 10.1002/smll.201302188. Epub 2014 Mar 26.
 
Kaz AM, Wong C-J, Dzieciatowski S, Luo YX, Schoen RE, Grady WM. Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics. 2014 Apr;9(4):492-502.
 
Luo Y, Wong CJ, Kaz AM, Morris SM, Dzieciatkowski S, Carter KT, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM. Global DNA Methylation Alterations Reveal Multiple Pathways in the Initiation and Progression of Colorectal Cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8 PMID:24793120
 
Shiovitz S, Bertagnolli MM, Renfro LA, Nam E, Foster NR, Dzieciatkowski S, Luo YX, Valinluck Lao V, Monnat RJ, Emond MJ, Maizels N, Niedzwiecki N, Goldberg RM, Saltz LB, Venook A, Warren RS, Grady WM. CpG Island Methylator Phenotype Predicts Improved Response to Adjuvant Therapy with Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B 89803 (Alliance). Gastroenterology. 2014 Sep;147(3):637-45.
 
Lao VV, Welsch P, Luo Y, Carter KT, Dzieciatkowski S, Dintzis S, Meza J, Sarvetnick NE, Monnat RJ, Loeb LA, Grady WM. Altered RECQ helicase expression in sporadic primary colorectal cancers. Translational Oncology. 2013 Aug 1; 6(4): 458-69. PMID 23908689.
 
Luo Y, Kaz AM, Kanngurn S, Welsch P, Moris SM, Wang JP, Lutterbaugh JD, Markowitz SD, Grady WM. NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. PLoS Genetics 2013. Jul; 9(7):epub. PMID 23874207.
 
Adams SV, Ahnen DJ, Baron JA, Campbell PT, Gallinger S, Grady WM, LeMarchnad L, Lindor NM, Potter JD, Newcomb PA. Survival after inflammatory bowel disease-associated cancer in the Colon Cancer Family Registry. World J Gastroenterology 2013. Jun 7;19(21):3241-8. PMID 23745025.
 
Burnett-Hartman AN, Newcomb PA, Potter JD, Passarelli MN, Phipps AI, Wurscher MA, Grady WM, Zhu LC, Upton MP, Makar KW. Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. Cancer Res. 2013 May 1;73(9):2863-72. doi: 10.1158/0008-5472.CAN-12-3462. Epub 2013 Mar 28.
 
Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports 2013; 3:1449. PMID: 23618955 PMCID: PMC3636513
 
Ulrich CM, Toriola AT, Siegel EM, Brenner H, Chang-Claude J, Abbenhardt C, Kotzmann J, Song X, Owen R, Hoffmeister M, Becher H, Shibata D, Potter JD, Kathy Vickers K, Rush SK, Makar K, Würtele G, Haupner R, Peters U, Sellers TA, Grady W. Plasma 25(OH)D3, folate, and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study. J of Nutritional Science 2013; 2:1-6.
 
Yu, Ming, Morris S, Trobridge P, Wang YX, Kanngurn S, Knoblaugh S, Grady WM. TGF-ß signaling inactivation cooperates with PTEN loss to induce intestinal cancer in vivo. Oncogene, 2013. epub. PMID 23604118
 
Hernandez JM, Siegel EM, Riggs B, Eschrich S, Elahi A, Qu X, Ajidahun A, Berglund A, Coppola D, Grady WM, Giuliano AR, Shibata D. DNA Methylation Profiling across the Spectrum of HPV-Associated Anal Squamous Neoplasia. PLoS One. 2012;7(11):2012 Nov 30. PMID: 23226306
 
Patel N, Black J, Chen X, Marcondes AM, Grady WM, Lawlor ER, Borinstein, SC. DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation. Sarcoma. 2012;2012:498472. Epub 2012 Sep 12. PMID: 23024594.
 
Luo Y, Tsuchiya KD, Park D-I, Fausel R, Kanngurn S, Dzieciatkowski S, Wang J-P, Grady WM. RET is a potential tumor suppressor gene in colorectal cancer. Oncogene 2012 July epub. PMID:22751117
 
Burnett-Hartman AN, Newcomb PA, Phipps AI, Passarelli MN, Grady WM, Upton MP, Zhu LC, Potter JD. Colorectal Endoscopy, Advanced Adenomas, and Sessile Serrated Polyps: Implications for Proximal Colon Cancer. Am J Gastroenterol. 2012 Jun 12 [Epub ahead of print]PMID:22688851.
 
Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI, Clurman BE. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol. 2012 Apr 2. [Epub ahead of print] PMID:22473991
 
Morris SM, Baek JY, Koszarek A, Kanngurn S, Knoblaugh SE, Grady WM. TGF-ß signaling promotes hepatocellular carcinogenesis induced by p53 loss. Hepatology 2012; 55:121-131. PMID: 21898503
 
Chak A, Chen Y, Vengoechea J, Canto M, Elston R, Falk GW, Grady WM, Guda K, Kinnard M, Markowitz SD, Mittal SK, Prasad GA, Shaheen NJ, Willis JE, Barnholtz-Sloan JS. Variation in age at cancer diagnosis in familial vs. non-familial Barrett’s esophagus. Cancer Epidemiol Biomarkers Prev. 2011 Dec 16. Epub. PMID 22178570
 
Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM. Aberrantly methylated PKP1 in the progression of Barrett’s esophagus to esophageal adenocarcinoma. Genes, Chromosomes, and Cancer, 2011; in press. PMID 22170739
 
Kaz AM, Wong C-J, Luo Y, Virgin JB, Washington MK, Willis JE, Leidner RS, Chak A, Grady WM. DNA Methylation Profiling in Barrett’s Esophagus and Esophageal Adenocarcinoma Reveals Unique Methylation Signatures and Molecular Subclasses. Epigenetics. 2011;6:1403-1412. PMID: 22139570
 
Greer KB, Thompson CL, Brenner L, Bednarchik B, Dawson D, Willis J, Grady WM, Falk GW, Cooper GS, Li L, Chak A. Association of insulin and insulin-like growth factors in Barrett’s oesophagus. Gut 2011. Epub. PMID 21930730
 
Cicek MS, Lindor NM, Gallinger S, Bapat B, Hopper JL, Jenkins MA, Young J, Buchanan D, Walsh MD, Le Marchand L, Burnett T, Newcomb PA, Grady WM, Haile RW, Casey G, Plummer SJ, Krumroy LA, Baron JA, Thibodeau SN. Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry. J Mol Diagn. 2011 May;13(3):271-81. PMID:21497289
 
Kim YH, Lee HC, Kim SY, Yeom YI, Ryu KJ, Min BH, Kim DH, Son HJ, Rhee PL, Kim JJ, Rhee JC, Kim HC, Chun HK, Grady WM, Kim YS. Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer Identifies Genes Commonly Affected by Epigenetic Alterations. Annals of Surgical Oncology. 2011 18(8): 2338-2347. PMID 21298349.
 
Holmes RS, Zheng Y, Baron JA, Li L, McKeown-Eyssen G, Newcomb PA, Stern MC, Haile RW, Grady WM, Potter JD, Le Marchand L, Campbell PT, Figueiredo JC, Limburg PJ, Jenkins MA, Hopper JL, Ulrich CM; for the Colon Cancer Family Registry. Use of Folic Acid-Containing Supplements after a Diagnosis of Colorectal Cancer in the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev. 2010;19:2023-2034.
 
Sun X, Elston R, Barnholtz-Sloan J, Falk G, Grady WM, Kinnard M, Mittal SK, Willis JE, Markowitz S, Brock W, Chak A. A Segregation Analysis of Barrett's Esophagus and Associated Adenocarcinomas. Cancer Epi Bio and Prevention 2010; 19:666-674. PMID: 20200424 PMC2838211 NIHMS194150
 
Borinstein SC, Conerly M, Dzieciatkowski S, Biswas S, Washington MK, Trobridge P, Henikoff S, Grady WM. Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Molecular Carcinogenesis 2010 Jan;49(1):94-103. PMID: 19777566
 
 
Ausch C, Kim YH, Tsuchiya KD, Dzieciatkowski S, Washington MK, Paraskeva C, Radich J, Grady WM. Comparative Analysis of PCR-Based Biomarker Assay Methods for Colorectal Polyp Detection from Fecal DNA. Clinical Chemistry 2009 Aug;55(8):1559-63. Epub 2009 Jun 18. PMID: 19541867 NIHMS190746
 
Chak A, Falk G, Grady WM, Kinnard M, Elston R, Mittal S, King JF, Willis JE, Kondru A, Brock W, Barnholtz-Sloan J. Assessment of Familiality, Obesity, and Other Risk Factors for Early Age of Cancer Diagnosis in Adenocarcinomas of the Esophagus and Gastroesophageal Junction. Am J Gastroenterol. 2009 Aug;104(8):1913-21. Epub 2009 Jun 2. PMID: 19491834
 
Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Ulrich C, Sasazuki T, Shiraswa S, Grady WM. TGF-β receptor inactivation cooperates with mutant Kras in vivo to induce intestinal neoplasms through a ß-catenin independent pathway. Gastroenterology. 2009; 136:1680-88. PMID: 19208363 PMC2782436
 
Rojas A, Padidam M, Cress D, Grady WM. TGF-ß receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-ß. Biochim Biophys Acta. 2009 Jul;1793(7):1165-73. Epub 2009 Feb 12.PMID: PMC2700179
 
Munoz N, Baek J-Y, Grady WM. TGF-ß has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. Growth Factors. 2008 Oct;26(5):254-62.PMID: 18651288 PMC2694855
 
Lynch HT, Kaurah P, Wirtzfeld D, Rubinstein WS, Weissman S, Lynch JF, Grady W, Wiyrick S, Senz J, Huntsman DG. Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy. Cancer 2008; 112:2655-63. PMID: 18442100 PMC2629639
 
Rojas A, Meherem S, Kim Y-H, Washington MK, Willis JE, Markowitz SD, Grady WM. The aberrant methylation of TSP1 suppresses TGF-β1 activation in colorectal cancer. International Journal of Cancer 2008, 123:14-21. PMID: 18425817 PMC2777657
 
Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim Y-H, Tsuchiya KD, Washington MK, Paraskeva C, Willson JKV, Kaz AM, Kroh EM, Allen A, Fritz BR, Markowitz SD, Tewari M. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 2008: 27:3880-3888. PMID: 18264139
 
Biswas S, Trobridge P, Romero-Gallo J, Billheimer D, Myeroff LL, Willson JKV, Markowitz SD, Grady WM. Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β (TGFB) resistant cells. Genes, Chromosomes and Cancer 2008: 95-106.
 
Veiseh M, Gabikian P, Bahrami SB, Veiseh O, Zhang M, Hackman RC, Ravanpay AC, Stroud MR, Kusuma Y, Hansen SJ, Kwok D, Munoz NM, Sze RW, Grady WM, Greenberg NM, Ellenbogen RG, Olson JM. Tumor paint: a chlorotoxin:cy5.5 bioconjugate for intraoperative visualization of cancer foci. Cancer Res. 2007;67(14):6882-8.
 
Ochs-Balcom HM, Falk G, Grady WM, Kinnard M, Willis J, Elston R, Eng C, Chak A. Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma.Translational Research. 2007;150(1):3-17.
 
Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng C-X, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR. KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 2007,11: 229-243.
 
Kaz A, Kim Y-H, Dzieciatkowski S, Lynch H, Watson P, Washington MK, Lin L, Grady WM. Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. International Journal of Cancer 2007, 120, 1922-1929.
 
Chak A, Faulx A, Eng C, Grady W, Kinard M, Ochs-Balcom H, Falk G. Gastroesophageal reflux symptoms in patients with adenocarcinoma of the esophagus or cardia. Cancer 2006; 107:2160-2166.
 
Chak A, Ochs-Balcom H, Falk G, Grady WM, Kinnard M, Willis JE, Elston R, Eng C. Familiality in Barrett’s esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction. Cancer Epidemiology Biomarkers and Prevention 2006; 15:1668-73.
 
Muñoz NM, Upton MP, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM. Transforming growth factor β receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Research 2006; 66, 9837-44.
 
Ye C, Shrubsole MJ, Cai Q, Ness R, Grady WM. Smalley W, Cai H, Washington K, Zheng W. Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. Oncology Reports 2006;2: 429-435.
 
Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM. CpG island methylation of genes accumulates during the adenoma progression step of the multi-step pathogenesis of colorectal cancer. Genes, Chromosomes, and Cancer 2006, 45:781-789.
 
Gray KD, Ballard BR, Washington MK, Belue,R, Grady WM, Chapman WC, Stain SC. Do adverse findings in colorectal cancer patients explain disparate outcomes? Journal of the National Medical Association, 2006: 98:348-351.
 
Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Guatam S, Markowitz SD. Proliferation and cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int. Journal of Cancer. 2006; 118:600-8.
 
Romero-Gallo J, Sozman E, Chytil A, Russell WE, Whitehead RW, Parks T, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM. Inactivation of TGF-ß signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene. 2005;24:3028-41.
 
Means AL, Chytil A, Moses HL, Coffey RJ, Wright CVE, Taketo MM, Grady WM, The Keratin 19 gene drives Cre recombinase expression throughout the early post-implantation mouse embryo. Genesis. 2005; 42:23-27.
 
Petko P, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM. Aberrantly methylated CDKN2A, MGMT and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clinical Cancer Research. 2005; 11:1203-1209.
 
Biswas S, Chytil A, Washington MK, Romero-Gallo J, Gorska, AE, Gautam S, Moses HL, Grady WM. TGFBR2 inactivation promotes the establishment and progression of colon cancer. Cancer Research 2004; 64:4687-4692.
 
Drovdlic DM, Goddard KAB, Chak A, Brock W, Chessler L, King JF, Richter J, Falk GW, Johnston DK, Fisher JL, Grady WM, Lemeshow S, Eng C. Demographic and Phenotypic Features of 70 Families Segregating Barrett Oesophagus and Oesophageal Adenocarcinoma. American Journal of Genetics 2003; 40: 651-656.
 
Grady WM. Genetic testing for high-risk colon cancer. Gastroenterology 2003, 124 (6);1573-1594.
 
Traicoff JL, Periyasamy S, Brattain MG, Grady W, Casey G. Reconstitution of TGF-ß sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7. Journal of Biomedical Science 2003; 10:253-259.
 
Grady WM, Rajput A, Lutterbaugh JD, Markowitz SD. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Research 2001; 61:900-902.
 
Grady WM, Willis J, Guilford PJ, Dunbier AK, Toro, TT, Lynch H, Weisner G, Ferguson K, Markowitz S. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics 2000; 26:16-17.
 
Lynch HT, Grady WM, Lynch JF, Tsuchiya KD, Weisner G, Markowitz SD. E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma. Cancer Genetics and Cytogenetics 2000; 122, 1-6.
 
Liu DF, Ferguson K, Cooper G, Grady WM, Willis J. p27 cell cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer. Journal of Clinical Laboratory Analysis 1999;13:291-295.
 
 
Guilford PJ, Hopkins JB, Grady WM, Markowitz SD, Willis J, Lynch H, Rajput A, Weisner GL, Lindor NM, Burgart LJ, Toto TT, Lee D, Limacher J-M, Shaw DW, Findlay MPN, Reeve AE. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Human Mutation 1999;14: 249-255.
 
Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim S-J, Kinzler KW, Vogelstein B, Willson JKV, Markowitz S. Mutational inactivation of transforming growth factor ß receptor type II in microsatellite stable colon cancers. Cancer Research 1999;59:320-324.
 
Grady WM, Rajput A, Myeroff L, Liu D, Kwon K, Willis J, Markowitz S. Mutation of the type II TGF-ß receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Research 1998;58:3101-3104.
 
Macdonald G, Greenson J, Delbuono E, Grady W, Merion R, Frank T, Lucey M, Appelman H. Mini-microabscess syndrome in liver transplant recipients. Hepatology 1997;26:192-197.
 
Waring W, Maynard F, Grady W, Grady R, Boyles C. Influence of appropriate lower extremity orthotic management on ambulation, pain, and fatigue in a postpolio population. Archives of Physical Medicine and Rehabilitation May 1989;70:371-75.