Lei

Yu

MD

Biography

Lei Yu, M.D. is a transplant hepatologist at UW Medicine and a UW associate professor of Gastroenterology.

Dr. Yu strives to create active partnerships with his patients to achieve the best possible outcomes.

Dr. Yu’s clinical interests include gastroenterology and hepatology. His research interests include the effect of diet and nutritional modification on chronic liver diseases.

Board Certifications

• Transplant Hepatology, 2018, American Board of Internal Medicine
• Gastroenterology, 2008, American Board of Internal Medicine

Education & Training

• Fellowship in Gastroenterology, University of Washington, 2009
• Master, University of Washington, 2009
• Residency, University of Maryland Hospital, 2004
• Internship. University of Maryland Hospital, 2002
• Medical Education, University of Maryland School of Medicine, 2001

Clinical Interests

• Gastroenterology (Digestive)
• Liver Transplant and Evaluation
• Hepatology (Liver)

Publications

Weiler S, Tsao D, Gruschus J, Yu L, Wang L-H, Nirenberg M and Ferretti J. Site-directed mutations in the vnd/NK-2 homeodomain, basis of variations in structure and sequence-specific DNA binding. J Biol Chem 1998; 273(18): 10994-11000. [Original work]

Yu L, Sloan D, Guo CF, Howell C. Risk Factors for Primary Hepatocellular Carcinoma in Black and White Americans in 2000. Clinical Gastroenterology and Hepatology 2006 Mar; 4(3): 355-360. [Original work]

Yu L, Ioannou G. Survival of liver transplant recipients with hemochromatosis in the United States. Gastroenterology 2007 Aug; 133(2): 489-95. [Original work]

Yu L, Koepsell T, Manhart L, Ioannou G. Survival after orthotopic liver transplantation: The impact of antibody against hepatitis B virus core antigen in the donor. Liver Transpl. 2009 Oct;15(10):1343-50. [Original work]

Yu L, Morishima C, Ioannou G. Dietary Cholesterol Intake is Associated with Progression of Liver Disease in Patients with Chronic Hepatitis C: Analysis of the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial. Clinical Gastroenterology and Hepatology 2013 Dec; 11(12):1661-6. [Original work]

Tartaglione E, Derleth M, Yu, L, Ioannou GN. Can computerized brain training games be used to identify early cognitive impairment in cirrhosis? American Journal of Gastroenterology 2014 Mar; 109(3):316-23. [Original work]

Yu L, Carithers, R. Liver Transplantation in the Elderly: An Evidence Based Review on Patient Outcome, Selection and Management Strategies. J Biomed Sci Eng 2014, Vol.7 No.9. [Review]

Yu L, Rayhill SC, Hsu EK, Landis CS. Liver Transplantation for Urea Cycle Disorders: Analysis of the United Network for Organ Sharing Database. Transplant Proc. 2015 Oct;47(8):2413-8. PMID: 26518943. [Original work]

*Yu L, Morishima C, Ioannou G. Sex difference in liver-related mortality and transplantation associated with dietary cholesterol in chronic hepatitis C virus infection. British J Nutr. 2016 Jan; 115(2):193-201. PMID:26541123. [Original work]

*Su F, *Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN. Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit. Gastroenterology. Gastroenterology. 2016 Feb;150(2):441-53. PMID: 26522262. [Original work] [* Joint first authorship]

Morrell A, Yu L, Burkhead JL. The role of insufficient copper in lipid synthesis and fatty liver disease. IUBMB Life 2017 Apr:69(4):263-270. Doi:10.1002/iub.1613. [Review]

Henriksen, E, Viken MK, Wittig M, Holm K, Trine Folseraas T, Mucha S, Melum E, Hov JR, Weersma RK, Bertus Eksteen B, Yimam K, Gordon S, Goldberg D, Yu L, Bowlus CL, Franke A, Lie BA and Karlsen TH. HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA 2017 Oct;90(4):228-233. Doi: 10.1111/tan 13076. [Collaboration]

Mariakakis A, Banks MA, Phillipi L, Yu L, Taylor J, Patel S. BiliScreen: Smartphone-based Scleral Jaundice Monitoring for Liver and Pancreatic Disorders. PACM on Interactive, Mobile, Wearable and Ubiquitous Technologies 2017 May:1(2): Article 20. Doi:10.1145/3090085 [Collaboration]

Choi AY, Jalikis, F, Westerhoff M, Boukhar S, Pulcini E, Damman C, Yu L. Searching for Bacterial Biofilm in Recurrent Cholangitis in Primary Sclerosing Cholangitis: A Case Presentation and Introduction of an Unexplored Disease Mechanism. Journal of Clinical and Translational Hepatology 2018 Mar 28;6(1):114-118. doi: 10.14218. PMID: 29577038. [Case Report]

Goldberg D, Assis D, Levy C, Yimam K, Eksteen B, Yu L, Rahimi R, Stuart G, Gordon S, Schwarz K, Verna E, Forman L, Bowlus C. Primary Sclerosing Cholangitis in Blacks is Not a Rare Clinical Entity in a Multi-Center North American Consortium. Clinical Gastroenterology and Hepatology 2018 Apr;16(4):591-593. doi: 10.1016. PMID: 29102704 [Collaboration]

Chapman T, Bowen SR, Yeung RH, Kwan S, Park JO, Yu L, Harris W, Johnson GE, Liou IW, Nyflot MJ, Apisarnthanarax S. Towards consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: defining clinically relevant liver toxicity endpoints. Practical Radiation Oncology 2018 May – June: 8(3):157-166. doi: 10.1016. PMID: 29426691 [Collaboration]

Bosch D, Koro K, Richards E, Hoch B, Jalikis F, Koch L, Swanson P, Truong C, Liou I, Yu L, Bhattacharya R, and Yeh MM. Validation of a Congestive Hepatic Fibrosis Scoring System. American Journal of Surgical Pathology 2019 Jun;43(6):766-772. doi: 10.1097/PAS.0000000000001250 [Collaboration]

Yu L, Iris W. Liou, Scott W. Biggins, Matthew Yeh, Florencia Jalikis, Lingtak-Neander Chan, Jason Burkhead. Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations. Hepatology Communications 2019. Jun 26;3(8):1159-1165. doi: 10.1002/hep4.1393. [Original work]

Apodaca MC, Wright AE, Riggins AM, Harris WP, Yeung RS, Yu L, Morishima C, Characterization of a Whole Blood Assay for Quantifying Myeloid-derived Suppressor Cells. Journal for Immuno Therapy of Cancer. 2019 Aug 28;7(1):230. doi: 10.1186/s40425-019-0674-1 [Collaboration]

Ikuta K, Roychoudhury P, Xie H, Mcclurkan CL, Walkiewicz M, Makhsous N, Huang ML, Beru Y, Alam M, Shepherd A, Lamotte ED, Patel K, Morris A, Ҫoruh B, Yu L, Bhattacharya R, Cheng R, Walter RB, Limaye AP, Lockwood CM, Holland SM, Rakita RM, Koelle DM, Greninger AL. Trillions and Trillions: Herpes Simplex Virus-1 Hepatitis in an Immunocompetent Adult. Open Forum Infect Dis. 2019 Nov 5;6(11):ofz465. doi: 10.1093/ofid/ofz465 [Collaboration]

Lynch KD, Chapman RW, Keshav S, Montano-Loza AJ, Kremer AE, Vetter M, Krijger M, Ponsioen CY, Trivedi P, Hirschfield G, Schramm C, Liu CH, Bowlus CL, Estes DJ, Pratt D, Hedin C, Bergquist A, de Vries AC, van der Woude CJ, Yu, L, Assis DN, Boyer J, Ytting H, Hallibasic E, Trauner M, Marschall HU, Daretti LM, Marzioni M, Yimam KK, Perin N, Floreani A, Beretta-Piccoli BT, Rogers JK, Levy C. Effects of Vedolizumab in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases. Clinical Gastroenterology and Hepatology 2020 Jan;18(1):179-187.e6. doi: 10.1016/j.cgh.2019.05.013. [Collaboration]